SynthesisBMC pulmonary medicine2012
Beta-blocker use and COPD mortality: a systematic review and meta-analysis.
Synthesis in BMC pulmonary medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Muscle sympathetic nerve activity in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Efficacy and Safety of Bisoprolol in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2023Pooled it
- Beta-blocker therapy in patients with COPD: a systematic literature review and meta-analysis with multiple treatment comparison.Respiratory research · 2021Pooled it
- Beta-blockers reduced the risk of mortality and exacerbation in patients with COPD: a meta-analysis of observational studies.PloS one · 2014Pooled it
- Metoprolol for the Prevention of Acute Exacerbations of COPD.The New England journal of medicine · 2019Trial
- β-Blocker Use and Clinical Outcomes in Patients With COPD Following Acute Myocardial Infarction.JAMA network open · 2024Article
- Associations Between Coronary Artery Calcium Score and Exacerbation Risk in BLOCK-COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Cardiovascular Prognosis of Subclinical Chronic Obstructive Pulmonary Disease in Patients with Suspected or Confirmed Coronary Artery Disease.International journal of chronic obstructive pulmonary disease · 2023Article
- Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOSI Register.Frontiers in cardiovascular medicine · 2022Article
- Impact of beta-blocker use on the long-term outcomes of heart failure patients with chronic obstructive pulmonary disease.ESC heart failure · 2021Article
- Review
- Effect of β-blockers on the risk of COPD exacerbations according to indication of use: the Rotterdam Study.ERJ open research · 2021Article
- The Impact of beta blockade on the cardio-respiratory system and symptoms during exercise.Current research in physiology · 2021Article
- Practical recommendations for the use of beta-blockers in chronic obstructive pulmonary disease.Expert review of respiratory medicine · 2020Review
- Impact of beta blockers on patients undergoing transcatheter aortic valve replacement: the OCEAN-TAVI registry.Open heart · 2020Observational
- Management of the COPD Patient with Comorbidities: An Experts Recommendation Document.International journal of chronic obstructive pulmonary disease · 2020Article
- Angina and chronic obstructive pulmonary disease: facing the perfect storm.European heart journal supplements : journal of the European Society of Cardiology · 2019Article
- Article
- Chronic obstructive pulmonary disease and β-blocker treatment in Asian patients with heart failure.ESC heart failure · 2018Observational
- Comparison of Long-Term Clinical Implications of Beta-Blockade in Patients With Obstructive Airway Diseases Exposed to Beta-Blockers With Different β1-Adrenoreceptor Selectivity: An Italian Population-Based Cohort Study.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the benefits of beta-blockers in patients with established or sub-clinical coronary artery disease, their use in patients with chronic obstructive pulmonary disease (COPD) has been controversial. Currently, no systematic review has examined the impact of beta-blockers on mortality in COPD.
methodsWe systematically searched electronic bibliographic databases including MEDLINE, EMBASE and Cochrane Library for clinical studies that examine the association between beta-blocker use and all cause mortality in patients with COPD. Risk ratios across studies were pooled using random effects models to estimate a pooled relative risk across studies. Publication bias was assessed using a funnel plot.
resultsOur search identified nine retrospective cohort studies that met the study inclusion criteria. The pooled relative risk of COPD related mortality secondary to beta-blocker use was 0.69 (95% CI: 0.62-0.78; I2=82%).
conclusionThe results of this review are consistent with a protective effect of beta-blockers with respect to all cause mortality. Due to the observational nature of the included studies, the possibility of confounding that may have affected these results cannot be excluded. The hypothesis that beta blocker therapy might be of benefit in COPD needs to be evaluated in randomised controlled trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.