Evidence map›Paper›PMID 22945852›Full record

ReviewGlycoconjugate journal2013

Analytical glycobiology at high sensitivity: current approaches and directions.

Milos V Novotny, William R Alley, Benjamin F Mann

Abstract readReview
In one paragraph

Review in Glycoconjugate journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Chemical Glycoproteomics.Chemical reviews · 2016
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Recent trends in analytical and structural glycobiology.Current opinion in chemical biology · 2013
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Milos V NovotnyDepartment of Chemistry, Indiana University, Bloomington, IN, USA. novotny@indiana.edu
William R Alley
Benjamin F Mann
Indiana University Bloomington · USGlomics (United States) · US

Funding

TRAININGP41RR018942 · NCRR · TRUSTEES OF INDIANA UNIVERSITY · PI REILLY, JAMES P. · 2005 to 2008
$3.9M
ULTRASENSITIVE METHODS FOR GLYCOCONJUGATE ANALYSISR01GM024349 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI NOVOTNY, MILOS · 1985 to 2014
$2.9M
Early Cancer Detection & Prognosis through GlycomicsU01CA128535 · NCI · TRUSTEES OF INDIANA UNIVERSITY · PI NOVOTNY, MILOS · 2007 to 2011
$1.9M
NCI NIH HHS 5U01CA128535NCI NIH HHS U01 CA128535NCRR NIH HHS P41 RR018942NCRR NIH HHS P41RR018942NIGMS NIH HHS 2R01GM024349NIGMS NIH HHS R01 GM024349
6 · The paper itself

Abstract

This review summarizes the analytical advances made during the last several years in the structural and quantitative determinations of glycoproteins in complex biological mixtures. The main analytical techniques used in the fields of glycomics and glycoproteomics involve different modes of mass spectrometry and their combinations with capillary separation methods such as microcolumn liquid chromatography and capillary electrophoresis. The need for high-sensitivity measurements have been emphasized in the oligosaccharide profiling used in the field of biomarker discovery through MALDI mass spectrometry. High-sensitivity profiling of both glycans and glycopeptides from biological fluids and tissue extracts has been aided significantly through lectin preconcentration and the uses of affinity chromatography.

Indexed as

GlycomicsChromatography, AffinityGlycoproteinsHumansLimit of DetectionMass SpectrometryGlycoproteins

Identifiers

PMID22945852
PMCPMC3586546
OpenAlexW2016795166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.