Evidence map›Paper›PMID 22945806›Full record

ReviewImmunologic research2013

Differentiation of innate type-2 effector cells.

Hua Huang, Xiaopeng Qi

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Basophils in antihelminth immunity.Seminars in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hua HuangDivision of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, CO 80206, USA. huangh@njhealth.org
Xiaopeng Qi
National Jewish Health · USUniversity of Colorado Denver · US

Funding

Gene Responses in Basophil-Mediated Allergic ResponsesR01AI083986 · NIAID · NATIONAL JEWISH HEALTH · PI HUANG, HUA · 2010 to 2014
$1.9M
Differentiation of Th2 cytokine-producing innate cellsR01AI059170 · NIAID · NATIONAL JEWISH HEALTH · PI HUANG, HUA · 2005 to 2009
$1.6M
Coordinating Adaptive and Innate ImmunityR01AI068083 · NIAID · NATIONAL JEWISH HEALTH · PI HUANG, HUA · 2005 to 2010
$1.4M
NIAID NIH HHS R01 AI059170NIAID NIH HHS R01 AI068083NIAID NIH HHS R01AI068083-04S1NIAID NIH HHS R01 AI083986NIAID NIH HHS R01AI083986
6 · The paper itself

Abstract

Type-2 immune responses are the underlying cause of many allergic diseases and provide protection against parasitic infection. Effective type-2 immune responses are generated by type-2 helper CD4(+) T cells (Th2) as well as type-2 innate effector cells. While we have learned a great deal about how CD4(+) Th2 cells regulate their Th2 cytokine gene transcription, we still do not know how type-2 innate effector cells acquire their capacity to express Th2 cytokine genes. Furthermore, it remains poorly understood how Th2 cytokines regulate the differentiation of innate type-2 progenitor cells. In this review, we will focus on (1) the long distance interaction between the sites of allergic inflammation and the site of hematopoiesis in the bone marrow, (2) the characteristics of innate type-2 progenitors, and (3) the molecular mechanisms by which innate type-2 effector cells acquire the capacity to produce type-2 cytokines.

Indexed as

AnimalsCell DifferentiationCytokinesGranulocytesHumansHypersensitivityInflammationMast CellsTh2 CellsCytokines

Identifiers

PMID22945806
PMCPMC3913171
OpenAlexW2032220032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.