ArticleArchives of general psychiatry2012
Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia.
Article in Archives of general psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ZNF804A Genetic Variation Confers Risk to Bipolar Disorder.Molecular neurobiology · 2016Pooled it
- Association between rs1344706 of ZNF804A and schizophrenia: a meta-analysis.Genomics, proteomics & bioinformatics · 2014Pooled it
- Gene Expressions Preferentially Influence Cortical Thickness of Human Connectome Project Atlas Parcellated Regions in First-Episode Antipsychotic-Naïve Psychoses.Schizophrenia bulletin open · 2023Article
- Imaging Genetics Towards a Refined Diagnosis of Schizophrenia.Frontiers in psychiatry · 2019Review
- Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies.Neuropsychiatric disease and treatment · 2019Article
- Control of CNS functions by RNA-binding proteins in neurological diseases.Current pharmacology reports · 2018Article
- ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals.Neuroscience bulletin · 2018Article
- The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project.Schizophrenia research · 2018Article
- Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment.Molecular psychiatry · 2018Article
- The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions.Molecular psychiatry · 2017Review
- The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association.PloS one · 2017Article
- Limited Evidence for Association of Genome-Wide Schizophrenia Risk Variants on Cortical Neuroimaging Phenotypes.Schizophrenia bulletin · 2016Article
- Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes.Journal of human genetics · 2016Article
- Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis.Translational psychiatry · 2015Article
- Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology.BMC medical genetics · 2015Article
- Imaging genetics and psychiatric disorders.Current molecular medicine · 2015Review
- Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia.Schizophrenia research · 2015Review
- Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.JAMA psychiatry · 2014Article
- ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies.Schizophrenia bulletin · 2014Article
- A schizophrenia risk gene, ZNF804A, is associated with brain white matter microstructure.Schizophrenia research · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
CONTEXT The single-nucleotide polymorphism rs1344706 in the gene ZNF804a has been associated with schizophrenia and with quantitative phenotypic features, including brain structure volume and the core symptoms of schizophrenia. OBJECTIVE To evaluate associations of rs1344706 with brain structure and the core symptoms of schizophrenia. DESIGN Case-control analysis of covariance. SETTING University-based research hospital. PARTICIPANTS Volunteer sample of 335 individuals with schizophrenia spectrum disorders (306 with core schizophrenia) and 198 healthy volunteers. MAIN OUTCOME MEASURES Cerebral cortical gray matter and white matter (WM) volumes (total and frontal, parietal, temporal, and occipital lobes), lateral ventricular cerebrospinal fluid volume, and symptom severity from the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms divided into 3 domains: psychotic, negative, and disorganized. RESULTS The rs1344706 genotype produced significant main effects on total, frontal, and parietal lobe WM volumes (F = 3.98, P = .02; F = 4.95, P = .007; and F = 3.08, P = .05, respectively). In the schizophrenia group, rs1344706 produced significant simple effects on total (F = 3.93, P = .02) and frontal WM volumes (F = 7.16, P < .001) and on psychotic symptom severity (F = 6.07, P = .003); the pattern of effects was concordant with risk allele carriers having larger volumes and more severe symptoms of disease than nonrisk homozygotes. In the healthy volunteer group, risk allele homozygotes had increased total WM volume compared with nonrisk allele carriers (F = 4.61, P = .03), replicating a previously reported association. CONCLUSIONS A growing body of evidence suggests that the risk allele of rs1347706 is associated with a distinctive set of phenotypic features in healthy volunteers and individuals with schizophrenia. Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom severity in schizophrenia.
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