ReviewDer Pathologe2012
The natural history of colorectal adenomas and early cancer.
Review in Der Pathologe, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Piecemeal Versus En Bloc Resection of Large Rectal Adenomas -A Prospective, Randomized Multicenter Study
Endoscopic Submucosal Dissection for Sessile Polyps and Laterally Spreading Lesions of the Colorectum Using a Selective Strategy - a Prospective Cohort Study
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Endoscopic Resection of Neoplasia in the Lower GI Tract: A Clinical Algorithm.Visceral medicine · 2024Review
- Metformin administration in prevention of colorectal polyps in type 2 diabetes mellitus patients.World journal of clinical cases · 2024Article
- Colorectal polyps increase the glycolytic activity.Frontiers in oncology · 2023Article
- Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization.BMC gastroenterology · 2021Article
- Endoscopy infection control strategy during the COVID-19 pandemic: experience from a tertiary cancer center in Brazil.Clinics (Sao Paulo, Brazil) · 2021Article
- Colorectal Cancer Screening Uptake: Differences Between Rural and Urban Privately-Insured Population.Frontiers in public health · 2020Article
- Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells.Cancer cell international · 2020Article
- Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.Journal of Cancer · 2020Review
- Mutation Profiling of Premalignant Colorectal Neoplasia.Gastroenterology research and practice · 2019Article
- Observational
- Mucinous adenocarcinoma of the umbilicus 8 years following anterior resection for villous adenoma of the rectum.Journal of surgical case reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenomas represent the morphological precursors of the vast majority of colorectal cancers: although every adenoma has the capacity of malignant evolution, most adenomas stabilize their progression or even regress. Pathological factors are predictive of the natural history of adenomas in terms of potential and time interval for becoming malignant. Regression of adenomas is histologically well established, but it is thought to be a dynamic process, with cycling phases of regression and growth. Colorectal carcinoma invading the submucosa but not the muscular layer represents the earliest form of clinically relevant colorectal cancer. Grade of differentiation of carcinoma, lymphovascular invasion, and state of the resection margin predict the risk of metastasis. Microstaging of invasive cancer together with tumuor budding allow the metastatic risk to be further stratified into minimal, low, and high. Two distinct profiles are identifiable in the natural history of cancerous adenomas: blocking the growth of early cancer and allowing its progression towards advanced cancer. Thus, biomarkers to distinguish between progressive and non-progressive pT1 neoplasia are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.