Evidence map›Paper›PMID 22945574›Full record

ReviewExperientia supplementum (2012)

Male reprotoxicity and endocrine disruption.

Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V McDonnell, Sara E Pacheco, Camelia Saffarini, Moses A Sandrof, Kim Boekelheide

Abstract readReview
In one paragraph

Review in Experientia supplementum (2012). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Lotus seed (Journal of traditional and complementary medicine · 2025
    Article
  4. Article
  5. Effect of Endocrine Disruptors on Testicular Function.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Phytoremediation of carbamazepine and its metabolite 10,11-epoxycarbamazepine by C3 and C4 plants.Environmental science and pollution research international · 2015
    Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sarah CampionDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
Natasha Catlin
Nicholas Heger
Elizabeth V McDonnell
Sara E Pacheco
Camelia Saffarini
Moses A Sandrof
Kim Boekelheide
Brown University · US

Funding

TRAINING IN ENVIRONMENTAL PATHOLOGYT32ES007272 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 1992 to 2021
$7.5M
Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine DisruptionR01ES017272 · NIEHS · BROWN UNIVERSITY · PI BOEKELHEIDE, KIM · 2010 to 2014
$2.7M
Xenotransplant CoreP20ES018169 · NIEHS · BROWN UNIVERSITY · PI GRUPPUSO, PHILIP A. · 2010 to 2012
$985k
NIEHS NIH HHS P20 ES018169NIEHS NIH HHS R01 ES017272NIEHS NIH HHS T32 ES007272
6 · The paper itself

Abstract

Mammalian reproductive tract development is a tightly regulated process that can be disrupted following exposure to drugs, toxicants, endocrine-disrupting chemicals (EDCs), or other compounds via alterations to gene and protein expression or epigenetic regulation. Indeed, the impacts of developmental exposure to certain toxicants may not be fully realized until puberty or adulthood when the reproductive tract becomes sexually mature and altered functionality is manifested. Exposures that occur later in life, once development is complete, can also disrupt the intricate hormonal and paracrine interactions responsible for adult functions, such as spermatogenesis. In this chapter, the biology and toxicology of the male reproductive tract is explored, proceeding through the various life stages including in utero development, puberty, adulthood, and senescence. Special attention is given to the discussion of EDCs, chemical mixtures, low-dose effects, transgenerational effects, and potential exposure-related causes of male reproductive tract cancers.

Indexed as

AgingAnimalsEndocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsGenitalia, MaleHumansMaleNeoplasms, Germ Cell and EmbryonalProstatic DiseasesPubertyReproductionTesticular NeoplasmsEndocrine DisruptorsEnvironmental Pollutants

Identifiers

PMID22945574
PMCPMC3650643
OpenAlexW85088222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.