ReviewExperientia supplementum (2012)
Heavy metal toxicity and the environment.
Review in Experientia supplementum (2012). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03495492 (Dermal Chelation Lowers White Blood Cell Count in Chronic Lymphocytic Leukemia), which is not on this map. Cited by 1,615 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dermal Chelation Lowers White Blood Cell Count in Chronic Lymphocytic Leukemia
Who cites it
1,615 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Endocrine-Immune Crosstalk in Pediatric Autoimmune Diseases: A Systematic Review of the Role of Micronutrients, with Emphasis on Vitamin D.Nutrients · 2026Pooled it
- Airborne contaminant exposure and bone development: a systematic review and meta-analysis.Toxicological sciences : an official journal of the Society of Toxicology · 2026Pooled it
- Cardioprotective effect of hydroalcoholic extract stem bark ofPharmaceutical biology · 2026Article
- Behavioural, neurochemical, and neurohistological effects of bisphenol A and vanadium following chronic co-administration in mice.IBRO neuroscience reports · 2026Article
- Health risk assessment of trace elements in plant-based cosmetics and personal care products using inductively coupled plasma-mass spectrometry (ICP-MS).RSC advances · 2026Article
- Quantum dot sensors for heavy metal detection: from mechanistic design to field deployment: a review.RSC advances · 2026Review
- Associations between a mixture of trace elements and bladder cancer occurrence: A study of possible reverse causation.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategies.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- The Protective Effects of Selenium Nanoparticles Against Metal Toxicity.Biological trace element research · 2026Review
- Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review.Journal of biochemical and molecular toxicology · 2026Review
- Structure-transport relationships in MXene-based membranes: from synthesis to selective water treatment.Nanoscale advances · 2026Review
- Dietary watermelon (Citrullus lanatus) rind mitigates nickel- and copper-induced hepatic, metabolic, and nrf2/keap1 signaling disruptions in Nile tilapia (Oreochromis niloticus).Veterinary research communications · 2026Article
- Comparative Determination of Lead, Cadmium, Mercury, and Arsenic in Commercial Dairy Products by Atomic Absorption Spectrometry and Inductively Coupled Plasma Optical Emission Spectrometry.Biological trace element research · 2026Article
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- Review
- Article
- The Role of Metals and Trace Elements in the Pathogenesis of Osteoarthritis and Other Rheumatic Diseases.International journal of molecular sciences · 2026Review
- Human Health Risk Assessment of Potentially Toxic Metals and Natural Radionuclides in Unrefined Edible Salts from Salt Mining Communities of Nasarawa State, Nigeria.Biological trace element research · 2026Article
- Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)-an arsenic-based herbicide-in horses in Brazil.Equine veterinary journal · 2026Article
- Identification and characterization of TrxA: a novel bacterial thioredoxin-metallothionein chimera.Applied microbiology and biotechnology · 2026Article
1,555 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Heavy metals are naturally occurring elements that have a high atomic weight and a density at least five times greater than that of water. Their multiple industrial, domestic, agricultural, medical, and technological applications have led to their wide distribution in the environment, raising concerns over their potential effects on human health and the environment. Their toxicity depends on several factors including the dose, route of exposure, and chemical species, as well as the age, gender, genetics, and nutritional status of exposed individuals. Because of their high degree of toxicity, arsenic, cadmium, chromium, lead, and mercury rank among the priority metals that are of public health significance. These metallic elements are considered systemic toxicants that are known to induce multiple organ damage, even at lower levels of exposure. They are also classified as human carcinogens (known or probable) according to the US Environmental Protection Agency and the International Agency for Research on Cancer. This review provides an analysis of their environmental occurrence, production and use, potential for human exposure, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.