Trial reportPediatrics2012
Implementation of a central line maintenance care bundle in hospitalized pediatric oncology patients.
Trial report in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03066596 (Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination
Who cites it
32 citing papers in PubMed, 119 citations in OpenAlex.
- Implementation of central venous access device care bundles using a plan-do-study-act approach to reduce central line-associated bloodstream infection in children at a tertiary hospital in Indonesia.Frontiers in pediatrics · 2026Article
- Implementation frameworks, strategies and outcomes in optimizing central venous access device practice in paediatrics: A scoping review.Journal of advanced nursing · 2025Article
- The National Paediatric Applied Research Translation Initiative (N-PARTI): using implementation science to improve primary care for Australian children with asthma, type 1 diabetes, and infections.BMC health services research · 2025Article
- Central Venous Catheter Complications in the Poisoning Emergency Center: A 5-Year Cross-Sectional Study.Advanced biomedical research · 2024Article
- Trainee educational curriculum to standardize central venous catheter repair.BMC medical education · 2023Article
- The evaluation of Candida-related central line-related bloodstream infections in pediatric cancer patients: A pre- and post-intervention study.Journal of infection prevention · 2023Article
- Central-line-associated bloodstream infections and central-line-associated non-CLABSI complications among pediatric oncology patients.Infection control and hospital epidemiology · 2023Article
- Can central venous access device care bundles and regular feedback reduce central line-associated complications in pediatric patients?Clinical and experimental pediatrics · 2021Article
- Impact of Perioperative Absolute Neutrophil Count on Central Line-Associated Bloodstream Infection in Children With Acute Lymphoblastic and Myeloid Leukemia.Frontiers in oncology · 2021Article
- Central line bundle including split-septum device and single-use prefilled flushing syringes to prevent port-associated bloodstream infections: a cost and resource-utilization analysis.BMC health services research · 2020Article
- Update on infection control practices in cancer hospitals.CA: a cancer journal for clinicians · 2018Review
- Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis.Bone marrow transplantation · 2017Review
- A contemporary approach to the prevention of peritoneal dialysis-related peritonitis in children: the role of improvement science.Pediatric nephrology (Berlin, Germany) · 2017Review
- Do Clinicians Understand Quality Metric Data? An Evaluation in a Twitter-Derived Sample.Journal of hospital medicine · 2017Article
- Reduced central line infection rates in children with leukemia following caregiver training: A quality improvement study.Medicine · 2016Article
- Surveillance of bloodstream infections in pediatric cancer centers - what have we learned and how do we move on?GMS hygiene and infection control · 2016Review
- State-Mandated Hospital Infection Reporting Is Not Associated With Decreased Pediatric Health Care-Associated Infections.Journal of patient safety · 2015Article
- [Essential measures for prehospital treatment of severely injured patients: The trauma care bundle].Der Unfallchirurg · 2015Article
- Tailoring International Pressure Ulcer Prevention Guidelines for Nigeria: A Knowledge Translation Study Protocol.Healthcare (Basel, Switzerland) · 2015Article
- Bloodstream infection in paediatric cancer centres--leukaemia and relapsed malignancies are independent risk factors.European journal of pediatrics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether a multidisciplinary, best-practice central line maintenance care bundle reduces central line-associated blood stream infection (CLABSI) rates in hospitalized pediatric oncology patients and to further delineate the epidemiology of CLABSIs in this population.
methodsWe performed a prospective, interrupted time series study of a best-practice bundle addressing all areas of central line care: reduction of entries, aseptic entries, and aseptic procedures when changing components. Based on a continuous quality improvement model, targeted interventions were instituted to improve compliance with each of the bundle elements. CLABSI rates and epidemiological data were collected for 10 months before and 24 months after implementation of the bundle and compared in a Poisson regression model.
resultsCLABSI rates decreased from 2.25 CLABSIs per 1000 central line days at baseline to 1.79 CLABSIs per 1000 central line days during the intervention period (incidence rate ratio [IRR]: 0.80, P = .58). Secondary analyses indicated CLABSI rates were reduced to 0.81 CLABSIs per 1000 central line days in the second 12 months of the intervention (IRR: 0.36, P = .091). Fifty-nine percent of infections resulted from Gram-positive pathogens, 37% of patients with a CLABSI required central line removal, and patients with Hickman catheters were more likely to have a CLABSI than patients with Infusaports (IRR: 4.62, P = .02).
conclusionsA best-practice central line maintenance care bundle can be implemented in hospitalized pediatric oncology patients, although long ramp-up times may be necessary to reap maximal benefits. Further research is needed to determine if this CLABSI rate reduction can be sustained and spread.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.