ReviewNature cell biology2012
Lineage conversion methodologies meet the reprogramming toolbox.
Review in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- dHyperCas12a enables multiplexed CRISPRi screens.Nature communications · 2026Article
- Cell phenotypic conversion and fate change during the host defense response, tissue injury and repair.Pharmacology & therapeutics · 2026Review
- Rewiring cell identityNanomedicine (London, England) · 2025Article
- HyperCas12a enables multiplexed CRISPRi screens.bioRxiv : the preprint server for biology · 2025Article
- Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors.Cell proliferation · 2025Article
- Article
- Engineered Extracellular Vesicle-Based Therapies for Valvular Heart Disease.Cellular and molecular bioengineering · 2023Article
- Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.Nature communications · 2023Article
- Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss.PloS one · 2021Article
- Cell Lineage Infidelity in PDAC Progression and Therapy Resistance.Frontiers in cell and developmental biology · 2021Review
- Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks.Nature communications · 2019Article
- L-type voltage-gated calcium channels in stem cells and tissue engineering.Cell proliferation · 2019Review
- Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine.Circulation research · 2019Review
- Bioinformatics analyses of publicly available NEPCa datasets.American journal of clinical and experimental urology · 2019Article
- Lineage Plasticity in Cancer Progression and Treatment.Annual review of cancer biology · 2018Article
- Elixir of Life: Thwarting Aging With Regenerative Reprogramming.Circulation research · 2018Review
- Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming.Stem cell reports · 2017Article
- Cellular reprogramming for clinical cartilage repair.Cell biology and toxicology · 2017Review
- A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue.Nature communications · 2017Article
- Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.Cell stem cell · 2017Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Lineage conversion has recently attracted increasing attention as a potential alternative to the directed differentiation of pluripotent cells to obtain cells of a given lineage. Different means allowing for cell identity switch have been reported. Lineage conversion relied initially on the discovery of specific transcription factors generally enriched and characteristic of the target cell, and their forced expression in cells of a different fate. This approach has been successful in various cases, from cells of the hematopoietic systems to neurons and cardiomyocytes. Furthermore, recent reports have suggested the possibility of establishing a general lineage conversion approach bypassing pluripotency. This requires a first phase of epigenetic erasure achieved by short overexpression of the factors used to reprogram cells to a pluripotent state (such as a combination of Sox2, Klf4, c-Myc and Oct4), followed by exposure to specific developmental cues. Here we present these different direct conversion methodologies and discuss their potential as alternatives to using induced pluripotent stem cells and differentiation protocols to generate cell populations of a given fate.
Indexed as
Identifiers
22945254What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.