ArticleOsteoarthritis and cartilage2012
Serum non-coding RNAs as biomarkers for osteoarthritis progression after ACL injury.
Article in Osteoarthritis and cartilage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
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- Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis- a systematic review.Osteoarthritis and cartilage open · 2023Review
- Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis.Frontiers in molecular biosciences · 2023Article
- Ribosome dysfunction in osteoarthritis.Current opinion in rheumatology · 2022Review
- LncRNA CTBP1-AS2 is upregulated in osteoarthritis and increases the methylation of miR-130a gene to inhibit chondrocyte proliferation.Clinical rheumatology · 2020Article
- Small Non-Coding RNAome of Ageing Chondrocytes.International journal of molecular sciences · 2020Article
- SnoRNA signatures in cartilage ageing and osteoarthritis.Scientific reports · 2020Article
- Expression signature of six-snoRNA serves as novel non-invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma.Journal of cellular and molecular medicine · 2020Article
- Association of circulating microRNAs with prevalent and incident knee osteoarthritis in women: the OFELY study.Arthritis research & therapy · 2020Article
- Non-Coding RNAs in Cartilage Development: An Updated Review.International journal of molecular sciences · 2019Review
- Epigenetics in osteoarthritis: Novel spotlight.Journal of cellular physiology · 2019Review
- Annotating Transcriptional Effects of Genetic Variants in Disease-Relevant Tissue: Transcriptome-Wide Allelic Imbalance in Osteoarthritic Cartilage.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- The lncRNA, Nespas, Is Associated with Osteoarthritis Progression and Serves as a Potential New Prognostic Biomarker.Cartilage · 2019Article
- RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage.Annals of the rheumatic diseases · 2019Article
- An Overview of MicroRNAs as Biomarkers of ALS.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of this study was to examine serum non-coding RNAs as potential biomarkers for cartilage damage associated with anterior cruciate ligament (ACL) injury.
methodsSerum was obtained from 80 patients 1 year after surgery for ACL injury and 60 normal donors without overt skeletal injury. Total serum RNA was isolated, small non-coding RNAs profiled by TaqMan array MicroRNA (miRNA) analysis and individual small RNA assays performed by quantitative TaqMan RT-PCR (qPCR). Semi-quantitative magnetic resonance imaging (MRI) analysis was performed using Whole Organ Magnetic Resonance Knee Score (WORMS) scoring for analysis of cartilage damage.
resultsInitial TaqMan array miRNA profiling showed an increased serum concentration of a small nucleolar RNA (snoRNA), U48, in five patients with cartilage damage compared with that in five patients without cartilage damage and six normal donors. Independent qPCR analysis of snoRNAs in serum from all patients and normal donors showed a strong association between the serum level of another snoRNA, U38, and cartilage damage in ACL injury patients and together with snoRNA, U48, clear distinction between ACL injury patients and normal donors.
conclusionSnoRNAs U38 and U48 are significantly elevated in the serum of patients developing cartilage damage at 1 year after ACL injury. Serum levels of U38 have the potential to facilitate early diagnosis of patients with cartilage damage after ACL injury. This study suggests serum non-coding RNAs may serve as novel noninvasive biomarkers for the detection and assessment of cartilage damage after ACL injury.
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