Evidence map›Paper›PMID 22944294›Full record

ReviewHuman pathology2013

Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.

Sylvia Hoeller, Yi Zhou, Rashmi Kanagal-Shamanna, Zijun Y Xu-Monette, Daniela Hoehn, Michel Bihl, Steven H Swerdlow, Andreas Rosenwald, German Ott, Jonathan Said and 8 more

Abstract readCase ReportsMulticenter StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Emergence ofEJHaem · 2024
    Article
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  13. Review
  14. Review
  15. Article
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  17. Review
  18. Efficacy and Safety of Ibrutinib in Indian Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma: Cases from a Named Patient Program.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Sylvia HoellerDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1439, USA.
Yi Zhou
Rashmi Kanagal-Shamanna
Zijun Y Xu-Monette
Daniela Hoehn
Michel Bihl
Steven H Swerdlow
Andreas Rosenwald
German Ott
Jonathan Said
Cherie H Dunphy
Carlos E Bueso-Ramos
Pei Lin
Michael Wang
Roberto N Miranda
Alexander Tzankov
L Jeffrey Medeiros
Ken H Young
The University of Texas MD Anderson Cancer Center · USUniversity Hospital of Basel · CHRobert Bosch Hospital · DEUniversity of Basel · CHUniversity of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USUniversity of Würzburg · DE

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Convergence of MicroRNAs and p53 Signaling in Multiple Myeloma: Environmental CoR01CA138688 · NCI · UNIVERSITY OF LOUISVILLE · PI LI, YONG · 2009 to 2017
$2.9M
Deep Sequencing of Small Regulatory RNAs in Diffuse Large B cell LymphomaRC1CA146299 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI XIAO, CHANGCHUN · 2009 to 2010
$1000k
NCATS NIH HHS UL1 TR000005NCI NIH HHS 1RC1CA146299NCI NIH HHS R01 CA138688NCI NIH HHS R01CA138688NCI NIH HHS RC1 CA146299
6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) share many features and both arise from CD5+ B-cells; their distinction is critical as MCL is a more aggressive neoplasm. Rarely, cases of composite MCL and CLL/SLL have been reported. Little is known about the nature of these cases and, in particular, the clonal relationship of the 2 lymphomas. Eleven composite MCL and CLL/SLL cases were identified. The clinical, morphologic and immunophenotypic features of the MCL and CLL/SLL were characterized. IGH (immunoglobulin heavy chain) gene analysis was performed on microdissected MCL and CLL/SLL components to assess their clonal relationship. Ten patients had lymphadenopathy, and 7 patients had bone marrow involvement. The MCL component had the following growth patterns: in situ (n = 1), mantle zone (n = 3), nodular and diffuse (n = 3), diffuse (n = 3), and interstitial in the bone marrow (the only patient without lymphadenopathy) (n = 1); 6 MCLs had blastoid or pleomorphic and 5 small lymphocytic features. The CLL/SLL component was nodular (n = 9) or diffuse (n = 2). All MCL were CD5(+) and cyclin D1(+) with t(11;14) translocation. All CLL/SLL were CD5(+), CD23(+) and negative for cyclin D1 or t(11;14). IGH gene analysis showed that the MCL and CLL/SLL components displayed different sized fragments, indicating that the MCL and CLL/SLL are likely derived from different neoplastic B-cell clones. The lack of a clonal relationship between the MCL and CLL/SLL components suggests that MCL and CLL/SLL components represent distinct disease processes and do not share a common progenitor B-cell.

Indexed as

AgedAged, 80 and overComposite LymphomaFemaleGene Rearrangement, B-LymphocyteHumansImmunoglobulin Heavy ChainsImmunophenotypingLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Mantle-CellMaleMiddle AgedImmunoglobulin Heavy Chains

Identifiers

PMID22944294
PMCPMC3640316
OpenAlexW2034321460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.