ReviewAnnals of the Royal College of Surgeons of England2012
The present state of treatments for articular cartilage defects in the knee.
Review in Annals of the Royal College of Surgeons of England, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcomes of surgical fixation of osteochondral fracture: a systematic review.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Pooled it
- Pooled it
- Cell-free biomimetic osteochondral scaffold for the treatment of knee articular surface lesions: Clinical outcomes differ based on patient and lesion characteristics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Conversion to Total Knee Arthroplasty After High Tibial Osteotomy: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2025Review
- Microfracture for medium size to large knee chondral defects has limited long-term efficacy: A systematic review.Journal of experimental orthopaedics · 2024Review
- Advances in 3D bioprinting for regenerative medicine applications.Regenerative biomaterials · 2024Review
- Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study.Journal of orthopaedic surgery and research · 2023Article
- Proteoglycans in Articular Cartilage and Their Contribution to Chondral Injury and Repair Mechanisms.International journal of molecular sciences · 2023Review
- Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling.NPJ Regenerative medicine · 2022Review
- Molecular mechanisms of exercise contributing to tissue regeneration.Signal transduction and targeted therapy · 2022Review
- Four cases report: Treatment of knee joint cartilage defects using autologous chondrocyte patch implantation.Frontiers in surgery · 2022Article
- Algorithm for Treatment of Focal Cartilage Defects of the Knee: Classic and New Procedures.Cartilage · 2021Review
- Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Chondrogenic differentiation of Wharton's Jelly mesenchymal stem cells on silk spidroin-fibroin mix scaffold supplemented with L-ascorbic acid and platelet rich plasma.Scientific reports · 2020Article
- Vibroarthrographic Signal Spectral Features in 5-Class Knee Joint Classification.Sensors (Basel, Switzerland) · 2020Article
- Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds.Journal of orthopaedic surgery and research · 2020Article
- Macrophage: A Potential Target on Cartilage Regeneration.Frontiers in immunology · 2020Review
- Cartilage Restoration in the Adolescent Knee: a Systematic Review.Current reviews in musculoskeletal medicine · 2019Review
- Analysis of patellofemoral arthrokinematic motion quality in open and closed kinetic chains using vibroarthrography.BMC musculoskeletal disorders · 2019Article
- Study of Telomere Length in Preimplanted Cultured Chondrocytes.Cartilage · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChondral and osteochondral lesions of the knee are notoriously difficult to treat due to the poor healing capacity of articular cartilage and the hostile environment of moving joints, ultimately causing disabling pain and early osteoarthritis. There are many different reconstructive techniques used currently but few are proven to be of value. However, some have been shown to produce a better repair with hyaline-like cartilage rather than fibrocartilage.
methodsA systematic search of all available online databases including PubMed, MEDLINE(®) and Embase™ was undertaken using several keywords. All the multiple treatment options and methods available were considered. These were summarised, and the evidence for and against them was scrutinised.
resultsA total of 460 articles were identified after cross-referencing the database searches using the keywords. These revealed that autologous and matrix assisted chondrocyte implantation demonstrated both 'good to excellent' histological results and significant improvement in clinical outcomes.
conclusionsAutologous and matrix assisted chondrocyte implantation have been shown to treat symptomatic lesions successfully with significant histological and clinical improvement. There is, however, still a need for further randomised clinical trials, perfecting the type of scaffold and the use of adjuncts such as growth factors. A list of recommendations for treatment and the potential future trends of managing these lesions are given.
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