Evidence map›Paper›PMID 22943038›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2012

Molecular imaging probe development: a chemistry perspective.

Donald D Nolting, Michael L Nickels, Ning Guo, Wellington Pham

Abstract read
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Hepatic glucose metabolism in the steatotic liver.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  8. Review
  9. Principles and Biomedical Application of Graphene Family Nanomaterials.Advances in experimental medicine and biology · 2022
    Article
  10. Review
  11. Article
  12. PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016
    Article
  13. Molecular probes for cardiovascular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Chelator-free synthesis of a dual-modality PET/MRI agent.Angewandte Chemie (International ed. in English) · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Donald D NoltingVanderbilt University Institute of Imaging Science.
Michael L Nickels
Ning Guo
Wellington Pham

Funding

Multifunctional Nanoparticles for Image-Guided Vaccine Delivery in CancerR01CA160700 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2012 to 2015
$1.3M
Neuro - Molecular Imaging of Delivery Across BBBK01AG026366 · NIA · VANDERBILT UNIVERSITY · PI PHAM, WELLINGTON · 2006 to 2010
$602k
NCI NIH HHS R01 CA160700NIA NIH HHS K01 AG026366
6 · The paper itself

Abstract

Molecular imaging is an attractive modality that has been widely employed in many aspects of biomedical research; especially those aimed at the early detection of diseases such as cancer, inflammation and neurodegenerative disorders. The field emerged in response to a new research paradigm in healthcare that seeks to integrate detection capabilities for the prediction and prevention of diseases. This approach made a distinct impact in biomedical research as it enabled researchers to leverage the capabilities of molecular imaging probes to visualize a targeted molecular event non-invasively, repeatedly and continuously in a living system. In addition, since such probes are inherently compact, robust, and amenable to high-throughput production, these probes could potentially facilitate screening of preclinical drug discovery, therapeutic assessment and validation of disease biomarkers. They could also be useful in drug discovery and safety evaluations. In this review, major trends in the chemical synthesis and development of positron emission tomography (PET), optical and magnetic resonance imaging (MRI) probes are discussed.

Identifiers

PMID22943038
PMCPMC3430472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.