Evidence map›Paper›PMID 22942912›Full record

ArticleBiomolecular concepts2012

The epsin protein family: coordinators of endocytosis and signaling.

Arpita Sen, Kayalvizhi Madhivanan, Debarati Mukherjee, R Claudio Aguilar

Open access · greenAbstract read
In one paragraph

Article in Biomolecular concepts, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  9. Review
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  11. Review
  12. Candida albicansmSphere · 2021
    Article
  13. Review
  14. Article
  15. Murine Epsins Play an Integral Role in Podocyte Function.Journal of the American Society of Nephrology : JASN · 2020
    Article
  16. EPSIN1 and MTV1 define functionally overlapping but molecularly distinctProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Arpita SenDepartment of Biological Sciences and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Kayalvizhi Madhivanan
Debarati Mukherjee
R Claudio Aguilar
Center for Cancer Research · USPurdue University West Lafayette · US

Funding

Interdisciplinary Cancer Prevention Research Internship ProgramR25CA128770 · NCI · PURDUE UNIVERSITY · PI TEEGARDEN, DOROTHY · 2008 to 2012
$1.5M
NCI NIH HHS R25 CA128770
6 · The paper itself

Abstract

The epsins are a conserved family of endocytic adaptors essential for cell viability in yeast and for embryo development in higher eukaryotes. Epsins function as adaptors by recognizing ubiquitinated cargo and as endocytic accessory proteins by contributing to endocytic network stability/regulation and membrane bending. Importantly, epsins play a critical role in signaling by contributing to epidermal growth factor receptor downregulation and the activation of notch and RhoGTPase pathways. In this review, we present an overview of the epsins and emphasize their functional importance as coordinators of endocytosis and signaling.

Identifiers

PMID22942912
PMCPMC3431554
OpenAlexW1986117283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.