ArticleCurrent neuropharmacology2012
Molecular and cellular pathways as a target of therapeutic hypothermia: pharmacological aspect.
Article in Current neuropharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Profile of MMP-9, MMP-9 mRNA Expression, -1562 C/T Polymorphism and Outcome in High-risk Traumatic Brain Injury: The Effect of Therapeutic Mild Hypothermia.Neurologia medico-chirurgica · 2017Trial
- Application of a thermoelectric cooling approach for localized hypothermia in a murine model.MethodsX · 2026Article
- Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants.International journal of molecular sciences · 2023Article
- Therapeutic Hypothermia Attenuates Cortical Interneuron Loss after Cerebral Ischemia in Near-Term Fetal Sheep.International journal of molecular sciences · 2023Article
- The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture.Frontiers in neuroscience · 2023Article
- Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia.Neural regeneration research · 2022Article
- Hypothermic Effect of Acute Citral Treatment during LPS-induced Systemic Inflammation in Obese Mice: Reduction of Serum TNF-α and Leptin Levels.Biomolecules · 2020Article
- Observational
- Measurement of the Intracochlear Hypothermia Distribution Utilizing Tympanic Cavity Hypothermic Rinsing Technique in a Cochlea Hypothermia Model.Frontiers in neurology · 2020Article
- Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome.Brain communications · 2020Article
- Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System.Oxidative medicine and cellular longevity · 2016Article
- Cooling techniques for targeted temperature management post-cardiac arrest.Critical care (London, England) · 2015Review
- Hypothermia: effects on platelet function and hemostasis.Thrombosis journal · 2014Article
- Oxidative stress and antioxidant activity in hypothermia and rewarming: can RONS modulate the beneficial effects of therapeutic hypothermia?Oxidative medicine and cellular longevity · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induced therapeutic hypothermia is the one of the most effective tools against brain injury and inflammation. Even though its beneficial effects are well known, there are a lot of pitfalls to overcome, since the potential adverse effects of systemic hypothermia are still troublesome. Without the knowledge of the precise mechanisms of hypothermia, it will be difficult to tackle the application of hypothermia in clinical fields. Better understanding of the characteristics and modes of hypothermic actions may further extend the usage of hypothermia by developing novel drugs based on the hypothermic mechanisms or by combining hypothermia with other therapeutic modalities such as neuroprotective drugs. In this review, we describe the potential therapeutic targets for the development of new drugs, with a focus on signal pathways, gene expression, and structural changes of cells. Theapeutic hypothermia has been shown to attenuate neuroinflammation by reducing the production of reactive oxygen species and proinflammatory mediators in the central nervous system. Along with the mechanism-based drug targets, applications of therapeutic hypothermia in combination with drug treatment will also be discussed in this review.
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