ArticleInternational journal of molecular sciences2012
Genome-wide analysis of DNA methylation and expression of microRNAs in breast cancer cells.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Overview of non-coding RNAs in breast cancers.Translational oncology · 2022Review
- The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.International journal of molecular sciences · 2021Review
- Review
- Impact of Natural OccurringInternational journal of molecular sciences · 2020Review
- A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer.PloS one · 2020Article
- Association of PON1 gene promoter DNA methylation with the risk of Clopidogrel resistance in patients with coronary artery disease.Journal of clinical laboratory analysis · 2019Article
- Genome-Wide DNA Methylation Patterns Analysis of Noncoding RNAs in Temporal Lobe Epilepsy Patients.Molecular neurobiology · 2018Article
- Hypomethylation of interleukin-6 (IL-6) gene increases the risk of essential hypertension: a matched case-control study.Journal of human hypertension · 2017Article
- The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population.PloS one · 2017Article
- Noncoding RNAs in breast cancer.Briefings in functional genomics · 2016Review
- Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health.Current opinion in pediatrics · 2015Review
- Article
- Article
- The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.Nature immunology · 2014Article
- The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas.BMC cancer · 2014Article
- Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.BioMed research international · 2014Article
- DNA methylation in ductal carcinoma in situ of the breast.Breast cancer research : BCR · 2013Review
- Global indiscriminate methylation in cell-specific gene promoters following reprogramming into human induced pluripotent stem cells.Stem cell reports · 2013Article
- Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.PloS one · 2013Article
- Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation of promoters is linked to transcriptional silencing of protein-coding genes, and its alteration plays important roles in cancer formation. For example, hypermethylation of tumor suppressor genes has been seen in some cancers. Alteration of methylation in the promoters of microRNAs (miRNAs) has also been linked to transcriptional changes in cancers; however, no systematic studies of methylation and transcription of miRNAs have been reported. In the present study, to clarify the relation between DNA methylation and transcription of miRNAs, next-generation sequencing and microarrays were used to analyze the methylation and expression of miRNAs, protein-coding genes, other non-coding RNAs (ncRNAs), and pseudogenes in the human breast cancer cell lines MCF7 and the adriamycin (ADR) resistant cell line MCF7/ADR. DNA methylation in the proximal promoter of miRNAs is tightly linked to transcriptional silencing, as it is with protein-coding genes. In protein-coding genes, highly expressed genes have CpG-rich proximal promoters whereas weakly expressed genes do not. This is only rarely observed in other gene categories, including miRNAs. The present study highlights the epigenetic similarities and differences between miRNA and protein-coding genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.