Trial reportInternational journal of molecular sciences2012
Effects of purified Saccharomyces cerevisiae (1→3)-β-glucan on venous ulcer healing.
Trial report in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Fungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation.Nutrients · 2026Review
- Beta-Glucan: A Macrophage Differentiation Modulator That Accelerates the Wound Healing Response.International wound journal · 2026Article
- Fungal exopolysaccharides as next-generation microbial biomaterials: molecular biosynthesis, structural architecture, and translational biomanufacturing strategies.Microbial cell factories · 2026Review
- Water-soluble yeast β-glucan accelerates oral ulcer healing in rats via collagen synthesis and epithelial regeneration.BMC oral health · 2026Article
- Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights.International wound journal · 2025Review
- Exploring the Properties and Application Potential of β-Glucan in Skin Care.Food science & nutrition · 2025Review
- Gut microbiota and stress ulcers: unraveling the neurotransmitter connection.Frontiers in neuroscience · 2025Review
- Research advances in fungal polysaccharides: production, extraction, characterization, properties, and their multifaceted applications.Frontiers in cellular and infection microbiology · 2025Review
- Immunomodulatory Effect and Biological Significance of β-Glucans.Pharmaceutics · 2023Review
- Transglycosylation of Stevioside by a Commercial β-Glucanase with Fungal Extracted β-Glucans as Donors.Waste and biomass valorization · 2023Article
- Article
- From Cancer Therapy to Winemaking: The Molecular Structure and Applications of β-Glucans and β-1, 3-Glucanases.International journal of molecular sciences · 2022Review
- Identification of Antibacterial Peptide Candidates Encrypted in Stress-Related and MetabolicPharmaceuticals (Basel, Switzerland) · 2022Article
- Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan-A Critical Review.Molecules (Basel, Switzerland) · 2019Review
- β-Glucans: Multi-Functional Modulator of Wound Healing.Molecules (Basel, Switzerland) · 2018Review
- Lung cancer and β-glucans: review of potential therapeutic applications.Investigational new drugs · 2017Review
- Effects of Low Molecular Weight Yeast β-Glucan on Antioxidant and Immunological Activities in Mice.International journal of molecular sciences · 2015Article
- Mechanochemical phosphorylation and solubilisation of β-D-glucan from yeast Saccharomyces cerevisiae and its biological activities.PloS one · 2014Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water-insoluble glucan was isolated from the baker's yeast Saccharomyces cerevisiae. The yeast cells were treated with alkali and the residue then with acid. Chemical and NMR (1D and 2D) analyses showed that a linear (1→3)-β-glucan was purified that was not contaminated with other carbohydrates, proteins or phenolic compounds. The effects of the glucan on wound healing were assessed in human venous ulcers by histopathological analysis after 30 days of topical treatment. (1→3)-β-glucan enhanced ulcer healing and increased epithelial hyperplasia, as well as increased inflammatory cells, angiogenesis and fibroblast proliferation. In one patient who had an ulcer that would not heal for over 15 years, glucan treatment caused a 67.8% decrease in the area of the ulcer. This is the first study to investigate the effects of (1→3)-β-glucan on venous ulcer healing in humans; our findings suggest that this glucan is a potential natural biological response modifier in wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.