ArticleCurrent genomics2012
Interference between DNA replication and transcription as a cause of genomic instability.
Article in Current genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
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- Non-Darwinian Molecular Biology.Frontiers in genetics · 2022Review
- Treacle Sticks the Nucleolar Responses to DNA Damage Together.Frontiers in cell and developmental biology · 2022Review
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- A recent development of new therapeutic agents and novel drug targets for cancer treatment.SAGE open medicine · 2021Review
- Recent advances in the nucleolar responses to DNA double-strand breaks.Nucleic acids research · 2020Review
- Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration.Scientific reports · 2019Article
- Drugging in the absence of p53.Journal of molecular cell biology · 2019Review
- Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication.Frontiers in cell and developmental biology · 2019Review
- Gene inversion potentiates bacterial evolvability and virulence.Nature communications · 2018Article
- Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.Nature communications · 2018Article
- Article
- Spatial and Temporal Control of Evolution through Replication-Transcription Conflicts.Trends in microbiology · 2017Article
- Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Replicating Large Genomes: Divide and Conquer.Molecular cell · 2016Review
- Replication Restart after Replication-Transcription Conflicts Requires RecA in Bacillus subtilis.Journal of bacteriology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Replication and transcription are key aspects of DNA metabolism that take place on the same template and potentially interfere with each other. Conflicts between these two activities include head-on or co-directional collisions between DNA and RNA polymerases, which can lead to the formation of DNA breaks and chromosome rearrangements. To avoid these deleterious consequences and prevent genomic instability, cells have evolved multiple mechanisms preventing replication forks from colliding with the transcription machinery. Yet, recent reports indicate that interference between replication and transcription is not limited to physical interactions between polymerases and that other cotranscriptional processes can interfere with DNA replication. These include DNA-RNA hybrids that assemble behind elongating RNA polymerases, impede fork progression and promote homologous recombination. Here, we discuss recent evidence indicating that R-loops represent a major source of genomic instability in all organisms, from bacteria to human, and are potentially implicated in cancer development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.