Evidence map›Paper›PMID 22942268›Full record

ArticlePeritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Frequency and microbiology of peritonitis and exit-site infection among obese peritoneal dialysis patients.

Sharon J Nessim, Paul Komenda, Claudio Rigatto, Mauro Verrelli, Manish M Sood

Open access · greenAbstract read
In one paragraph

Article in Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. The HONEYPOT randomized controlled trial statistical analysis plan.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
    Trial
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Oral Colonization ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018
    Article
  13. Validation of the Kidney Failure Risk Equation in Manitoba.Canadian journal of kidney health and disease · 2017
    Article
  14. Coagulase-negative staphylococci.Clinical microbiology reviews · 2014
    Review
  15. Effect of body mass index on outcomes of peritoneal dialysis patients in India.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2014
    Observational
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sharon J NessimDivision of Nephrology, Jewish General Hospital, and McGill University, Montreal, Quebec, Canada. sharon.nessim@mcgill.ca
Paul Komenda
Claudio Rigatto
Mauro Verrelli
Manish M Sood
Seven Oaks General Hospital · CACanadian Society of Nephrology · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on obesity as a risk factor for peritonitis and catheter infections among peritoneal dialysis (PD) patients are limited. Furthermore, little is known about the microbiology of PD-related infections among patients with a high body mass index (BMI).

methodsUsing a cohort that included all adult patients residing in the province of Manitoba who received PD during the period 1997 - 2007, we studied the relationship between BMI and PD-related infections. After categorizing patients into quartiles of BMI, a multivariate Cox regression model was used to determine the independent relationship between BMI and peritonitis or exit-site infection (ESI). We also studied whether increasing BMI was associated with a propensity to infections with particular organisms.

resultsAmong 990 PD patients, 938 (95%) had accurate BMI data available. Those 938 patients experienced 1338 peritonitis episodes and 1194 exit-site infections. In unadjusted analyses, patients in the highest BMI quartile (median: 33.5; interquartile range: 31.9 - 36.4) had an increased risk of peritonitis overall, and also an increased risk of peritonitis with gram-positive organisms and coagulase-negative Staphylococcus (CNS). After multivariate adjustment for age, sex, diabetes, cause of renal disease, Aboriginal race, PD modality, and S. aureus nasal carriage, the relationship between overall peritonitis risk and BMI disappeared, but the increased risk of CNS peritonitis among patients in the highest BMI quartile persisted (hazard ratio: 1.80; 95% confidence interval: 1.06 to 3.06; p = 0.03). There was no increased risk of ESI among patients in the highest BMI quartile on univariate analysis or after multivariate adjustment.

conclusionsAmong Canadian PD patients, obesity was not associated with an increased risk of peritonitis overall, but may be associated with a higher risk of CNS peritonitis.

Indexed as

AdultAgedBody Mass IndexCanadaCatheters, IndwellingCohort StudiesFemaleHumansKidney Failure, ChronicMaleMiddle AgedObesityPeritoneal DialysisPeritonitisRisk FactorsStaphylococcal Infections

Identifiers

PMID22942268
PMCPMC3598106
OpenAlexW2113046274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.