Evidence map›Paper›PMID 22942082›Full record

ArticleJournal of genetics2012

Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist.

Yanhong Cao, Jifei Zhang, Yan Jiao, Jian Yan, Feng Jiao, Xiaoyun Liu, Robert W Williams, Karen A Hasty, John M Stuart, Weikuan Gu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yanhong CaoInstitute of Kaschin-Beck Disease, Center for Endemic Disease Control, Centers for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, People's Republic of China.
Jifei Zhang
Yan Jiao
Jian Yan
Feng Jiao
Xiaoyun Liu
Robert W Williams
Karen A Hasty
John M Stuart
Weikuan Gu
Campbell Clinic · USUniversity of Tennessee Health Science Center · USHarbin Medical University · CNMudanjiang Medical University · CN

Funding

NIAMS NIH HHS R01 AR50785NIAMS NIH HHS R01 AR51190
6 · The paper itself

Abstract

Rheumatoid arthritis is a heterogeneous disease with clinical and biological polymorphisms. IL-1RN is a protein that binds to interleukin-1 (IL-1) receptors and inhibits the binding of IL-1-alpha and IL-1-beta. IL-1RN levels are elevated in the blood of patients with a variety of infectious, immune, and traumatic conditions. Balb/c mice deficient in IL-1ra (mouse gene of IL-1RN) develop spontaneous autoimmune arthritis while DBA/1 mice deficient in IL-1ra do not. Previously, we identified a major QTL that regulates the susceptibility to arthritis in Balb/c mice with IL-1ra deficiency. In this study, we found that the QTL may contain two peaks that are regulated by two sets of candidate genes. By haplotype analysis, the total genomic regions of candidate genes were reduced from about 19 Mbp to approximately 9 Mbp. The total number of candidate genes was reduced from 208 to 21.

Indexed as

Quantitative Trait LociAnimalsArthritis, ExperimentalArthritis, RheumatoidChromosome MappingChromosomes, MammalianCyclooxygenase 2Gene ExpressionGene Regulatory NetworksGenetic Association StudiesGenetic MarkersGroup IV Phospholipases A2Interleukin 1 Receptor Antagonist ProteinMiceMice, Inbred BALB CMice, Inbred DBACyclooxygenase 2Genetic MarkersGroup IV Phospholipases A2Il1rn protein, mouseInterleukin 1 Receptor Antagonist ProteinPla2g4a protein, mousePrg4 protein, mouseProteoglycan 4ProteoglycansPtgs2 protein, mouse

Identifiers

PMID22942082
OpenAlexW2071284362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.