ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2012
Retinoic acid expands the evolutionarily reduced dentition of zebrafish.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury.Cell proliferation · 2026Article
- Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish.Development (Cambridge, England) · 2025Article
- Challenging and redefining Dollo's law of evolution: re-appearance of lost structures.BMC ecology and evolution · 2025Review
- The Secretome of the Inductive Tooth Germ Exhibits Signals Required for Tooth Development.Bioengineering (Basel, Switzerland) · 2025Article
- Experimental induction of supernumerary teeth in zebrafish: Oral teeth perhaps, dorsal teeth for sure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reply to Huysseune and Witten: Oral tooth bud formation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Blocking endogenous retinoic acid degradation induces oral tooth formation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Article
- The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.Stem cells international · 2020Article
- New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures.Biomolecules · 2019Review
- The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish.Proceedings. Biological sciences · 2019Article
- Zebrafish skeleton development: High resolution micro-CT and FIB-SEM block surface serial imaging for phenotype identification.PloS one · 2017Article
- Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly.Genome biology · 2016Article
- Citalopram and sertraline exposure compromises embryonic bone development.Molecular psychiatry · 2016Article
- [Retinoic acid signal pathway regulation of zebra fish tooth development through manipulation of the differentiation of neural crest].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Article
- Retinoic Acid Excess Impairs Amelogenesis Inducing Enamel Defects.Frontiers in physiology · 2016Article
- Hedgehog signaling regulates dental papilla formation and tooth size during zebrafish odontogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Altered retinoic acid signalling underpins dentition evolution.Proceedings. Biological sciences · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
Zebrafish lost anterior teeth during evolution but retain a posterior pharyngeal dentition that requires retinoic acid (RA) cell-cell signaling for its development. The purposes of this study were to test the sufficiency of RA to induce tooth development and to assess its role in evolution. We found that exposure of embryos to exogenous RA induces a dramatic anterior expansion of the number of pharyngeal teeth that later form and shifts anteriorly the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b. After RA exposure, we also observed a correlation between cartilage malformations and ectopic tooth induction, as well as abnormal cranial neural crest marker gene expression. Additionally, we observed that the RA-induced zebrafish anterior teeth resemble in pattern and number the dentition of fish species that retain anterior pharyngeal teeth such as medaka but that medaka do not express the aldh1a2 RA-synthesizing enzyme in tooth-forming regions. We conclude that RA is sufficient to induce anterior ectopic tooth development in zebrafish where teeth were lost in evolution, potentially by altering neural crest cell development, and that changes in the location of RA synthesis correlate with evolutionary changes in vertebrate dentitions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.