Evidence map›Paper›PMID 22941978›Full record

ReviewExperimental physiology2012

Stress-dependent hypertension and the role of T lymphocytes.

Paul J Marvar, David G Harrison

Open access · bronzeAbstract readReview
In one paragraph

Review in Experimental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Objective and Measurable Biomarkers in Chronic Subjective Tinnitus.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Targeting vascular (endothelial) dysfunction.British journal of pharmacology · 2017
    Review
  15. Review
  16. Systemic leukotriene BThe Journal of physiology · 2016
    Article
  17. Blood pressure regulation by CD4Nature biotechnology · 2016
    Article
  18. The multifaceted mineralocorticoid receptor.Comprehensive Physiology · 2014
    Review
  19. Autoimmunity in the pathogenesis of hypertension.Nature reviews. Nephrology · 2014
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Paul J MarvarDepartment of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA. pmarvar@emory.ed
David G Harrison
Emory University · USVanderbilt University · US

Funding

Vascular specific ACE expression and atherosclerosisP01HL058000 · NHLBI · VANDERBILT UNIVERSITY · PI DIKALOV, SERGEY · 1998 to 2013
$20.7M
T cell triggering events and hypertensionP01HL095070 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2009 to 2019
$20.5M
Therapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5M
REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUMR01HL039006 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 1987 to 2017
$5.5M
Roles of oxidation and inflammation in aortic stiffeningR01HL105294 · NHLBI · VANDERBILT UNIVERSITY · PI HARRISON, DAVID G · 2010 to 2013
$1.5M
Stress-induced hypertension and the role of the neuroimmune systemK99HL107675 · NHLBI · EMORY UNIVERSITY · PI MARVAR, PAUL J · 2011 to 2012
$111k
NHLBI NIH HHS K99 HL107675NHLBI NIH HHS K99HL107675NHLBI NIH HHS P01 HL058000NHLBI NIH HHS P01HL058000NHLBI NIH HHS P01 HL095070NHLBI NIH HHS P01HL095070NHLBI NIH HHS R01 HL039006NHLBI NIH HHS R01HL039006NHLBI NIH HHS R01 HL105294NHLBI NIH HHS R01HL105294-02NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P01GM015431
6 · The paper itself

Abstract

Hypertension is a significant global health burden that is associated with an increased risk of stroke, atherosclerosis and other cardiovascular diseases. Several risk factors, including high dietary salt, obesity, genetics and race, as well as behavioural and psychological factors, contribute to development of this complex disease. Various hypertensive stimuli enhance sympathetic drive and promote autonomic dysfunction leading to elevated blood pressure. As our understanding of the pathogenesis and end-organ damage associated with hypertension increases, mounting evidence also highlights the role of inflammation in this process and, in particular, the role of the adaptive immune system and T cells. This review discusses recent findings regarding the role of the central nervous system, T lymphocytes and the impact of cardiovascular risk factors, such as psychological stress, in hypertension.

Indexed as

AnimalsCentral Nervous SystemHumansHypertensionRisk FactorsStress, PsychologicalT-Lymphocytes

Identifiers

PMID22941978
PMCPMC4654775
OpenAlexW1574015505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.