ArticleJournal of lipid research2012
Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Article in Journal of lipid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects.Molecular neurobiology · 2018Trial
- Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women.Lipids in health and disease · 2018Trial
- Alpha-lipoic Acid: An Antioxidant with Anti-aging Properties for Disease Therapy.Current medicinal chemistry · 2025Review
- Alpha-Lipoic Acid Induces Adipose Tissue Browning through AMP-Activated Protein Kinase SignalingJournal of obesity & metabolic syndrome · 2024Article
- Limited oxygen in standard cell culture alters metabolism and function of differentiated cells.The EMBO journal · 2024Article
- Brown AlgaeMarine drugs · 2024Article
- α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?Nutrients · 2023Review
- Sudachitin and Nobiletin Stimulate Lipolysis via Activation of the cAMP/PKA/HSL Pathway in 3T3-L1 Adipocytes.Foods (Basel, Switzerland) · 2023Article
- Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized trials.Endocrine connections · 2022Article
- Potential lipolytic regulators derived from natural products as effective approaches to treat obesity.Frontiers in endocrinology · 2022Review
- Study of the Lipolysis Effect of Nanoliposome-EncapsulatedFoods (Basel, Switzerland) · 2021Article
- Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK.Adipocyte · 2020Article
- 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells.BMC complementary and alternative medicine · 2019Article
- Article
- Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development.Journal of physiology and biochemistry · 2018Article
- FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice.Journal of lipid research · 2015Article
- Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.Nature medicine · 2015Article
- 11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue.American journal of physiology. Endocrinology and metabolism · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipoic acid (LA) is a naturally occurring compound with beneficial effects on obesity. The aim of this study was to evaluate its effects on lipolysis in 3T3-L1 adipocytes and the mechanisms involved. Our results revealed that LA induced a dose- and time-dependent lipolytic action, which was reversed by pretreatment with the c-Jun N-terminal kinase inhibitor SP600125, the PKA inhibitor H89, and the AMP-activated protein kinase activator AICAR. In contrast, the PI3K/Akt inhibitor LY294002 and the PDE3B antagonist cilostamide enhanced LA-induced lipolysis. LA treatment for 1 h did not modify total protein content of hormone-sensitive lipase (HSL) but significantly increased the phosphorylation of HSL at Ser(563) and at Ser(660), which was reversed by H89. LA treatment also induced a marked increase in PKA-mediated perilipin phosphorylation. LA did not significantly modify the protein levels of adipose triglyceride lipase or its activator comparative gene identification 58 (CGI-58) and inhibitor G(0)/G(1) switch gene 2 (G0S2). Furthermore, LA caused a significant inhibition of adipose-specific phospholipase A2 (AdPLA) protein and mRNA levels in parallel with a decrease in the amount of prostaglandin E(2) released and an increase in cAMP content. Together, these data suggest that the lipolytic actions of LA are mainly mediated by phosphorylation of HSL through cAMP-mediated activation of protein kinase A probably through the inhibition of AdPLA and prostaglandin E(2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.