ArticleInternational urology and nephrology2012
Development of a nomogram to predict non-organ-confined bladder urothelial cancer before radical cystectomy.
Article in International urology and nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Association Between Preoperative Hydronephrosis and Prognosis After Radical Cystectomy Among Patients With Bladder Cancer: A Systemic Review and Meta-Analysis.Frontiers in oncology · 2019Pooled it
- A systematic review and meta-analysis of the impact of lymphovascular invasion in bladder cancer transurethral resection specimens.BJU international · 2019Pooled it
- Using machine learning for predicting cancer-specific mortality in bladder cancer patients undergoing radical cystectomy: a SEER-based study.BMC cancer · 2025Article
- Development and validation of a preoperative nomogram to predict lymph node metastasis in patients with bladder urothelial carcinoma.Journal of cancer research and clinical oncology · 2023Article
- A new model to predict acute kidney injury after cardiac surgery in patients with renal insufficiency.Renal failure · 2022Article
- Management of Bladder Cancer Patients with Clinical Evidence of Lymph Node Invasion (cN+).Cancers · 2022Review
- A Prognostic Nomogram Based on Log Odds of Positive Lymph Nodes to Predict Overall Survival for Non-Metastatic Bladder Cancer Patients after Radical Cystectomy.Current oncology (Toronto, Ont.) · 2022Article
- Development and Validation of a Prognostic Nomogram for Predicting Overall Survival for T1 High-Grade Patients After Radical Cystectomy: A Study Based on SEER.International journal of general medicine · 2022Article
- Development and validation of a model for predicting acute kidney injury after cardiac surgery in patients of advanced age.Journal of cardiac surgery · 2021Article
- Predictive Nomogram and Risk Factors for Lymph Node Metastasis in Bladder Cancer.Frontiers in oncology · 2021Article
- Development and validation of a prognostic nomogram for predicting cancer-specific survival after radical cystectomy in patients with bladder cancer:A population-based study.Cancer medicine · 2020Article
- Nomograms for predicting long-term overall survival and cancer-specific survival in patients with primary urethral carcinoma: a population-based study.International urology and nephrology · 2020Article
- Identification and validation of an 18-gene signature highly-predictive of bladder cancer metastasis.Scientific reports · 2018Article
- The prognostic role of lymphovascular invasion in urothelial carcinoma of the bladder.Nature reviews. Urology · 2016Review
- Clinical and therapeutic factors associated with adverse pathological outcomes in clinically node-negative patients treated with neoadjuvant cisplatin-based chemotherapy and radical cystectomy.World journal of urology · 2016Article
- External validation of existing nomograms predicting lymph node metastases in cystectomized patients.International journal of clinical oncology · 2015Article
- Scoring system for prediction of lymph node metastasis in radical cystectomy cohort.International urology and nephrology · 2014Article
- [C-reactive protein prior to radical cystectomy: preoperative determination of CRP].Der Urologe. Ausg. A · 2014Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo create a preoperative prediction model for estimating the risk of non-organ-confined (pT3-4 or pN+) bladder urothelial cancer (NOC-BUC) in patients with clinically OC-BUC (cT1-2N0M0).
methodsThe study involved 248 consecutive patients who had undergone radical surgery for clinically OC-BUC at a tertiary cancer center between 2003 and 2011. Logistic regression analysis was used to develop a prediction model for estimating the risk of pathological NOC disease. Prespecified predictors included age, gender, recurrent frequency, tumor size and number, hydronephrosis, and pathological characteristics at transurethral resection (T-stage, tumor grade, lymphovascular invasion (LVI), and carcinoma in situ). Discrimination ability was measured by the area under the receiver operating characteristic curve (AUC).
resultsOverall, 39.1 % of the patients with clinically OC-BUC had NOC disease at the time of radical surgery. In multivariate analysis, recurrent frequency, tumor size, hydronephrosis, and three pathological features at transurethral resection (T-stage, tumor grade, and LVI) were significantly associated with disease extent. The final prediction model included seven variables after backward elimination and achieved a bootstrap-corrected AUC of 0.79. Internal validation showed good calibration and clinical usefulness of the nomogram.
conclusionsBased on readily available clinicopathological parameters, we developed a nomogram for predicting NOC tumor in clinically OC-BUC. Despite reasonable performance in internal validation, the prediction model should be assessed in external dataset before applied in clinical setting.
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