ArticleJournal of leukocyte biology2012
Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.
Article in Journal of leukocyte biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.Cellular and molecular life sciences : CMLS · 2023Article
- Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases.Clinical microbiology reviews · 2021Review
- The Timing and Abundance of IL-2Rβ (CD122) Expression Control ThymicFrontiers in immunology · 2021Article
- The transcription factor BCL-6 controls early development of innate-like T cells.Nature immunology · 2020Article
- CD24Immune network · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.Nature communications · 2018Article
- IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation.Mucosal immunology · 2016Article
- Innate memory T cells.Advances in immunology · 2015Review
- Jarid2 is induced by TCR signalling and controls iNKT cell maturation.Nature communications · 2014Article
- Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.Nature immunology · 2013Article
- The mechanism of splenic invariant NKT cell activation dictates localization in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IL-4 and IL-4 receptor expression is dispensable for the development and function of natural killer T cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed the production of the canonical Th2 cytokine IL-4 by NKT cells directly in vivo using IL-4-substituting strains of reporter mice that provide faithful and sensitive readouts of cytokine production without the confounding effects of in vitro stimulation. Analysis in naïve animals revealed an "innate" phase of IL-4 secretion that did not need to be triggered by administration of a known NKT cell ligand. This secretion was by immature NKT cells spanning Stage 1 of the maturation process in the thymus (CD4(+) CD44(lo) NK1.1(-) cells) and Stage 2 (CD4(+) CD44(hi) NK1.1(-) cells) in the spleen. Like ligand-induced IL-4 production by mature cells, this innate activity was independent of an initial source of IL-4 protein and did not require STAT6 signaling. A more sustained level of innate IL-4 production was observed in animals on a BALB/c background compared with a C57BL/6 background, suggesting a level of genetic regulation that may contribute to the "Th2-prone" phenotype in BALB/c animals. These observations indicate a regulated pattern of IL-4 expression by maturing NKT cells, which may endow these cells with a capacity to influence the development of surrounding cells in the thymus.
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