ArticleNucleic acids research2012
Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Quantification of Differential Response of Tumour and Normal Cells to Microbeam Radiation in the Absence of FLASH Effects.Cancers · 2021Article
- Radiation-Induced Bystander Effect: Loss of Radioprotective Capacity of Rosmarinic Acid In Vivo and In Vitro.Antioxidants (Basel, Switzerland) · 2021Article
- Synchrotron X-Ray Radiation-Induced Bystander Effect: An Impact of the Scattered Radiation, Distance From the Irradiated Site and p53 Cell Status.Frontiers in oncology · 2021Article
- Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.Nucleic acids research · 2020Article
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- Review
- Track to the future: historical perspective on the importance of radiation track structure and DNA as a radiobiological target.International journal of radiation biology · 2018Review
- The effect of 1.5 T cardiac magnetic resonance on human circulating leucocytes.European heart journal · 2018Article
- Compromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity.Cancer letters · 2016Article
- Comments on potential health effects of MRI-induced DNA lesions: quality is more important to consider than quantity.European heart journal. Cardiovascular Imaging · 2016Review
- Role of nitric oxide in the radiation-induced bystander effect.Redox biology · 2015Review
- NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- DDR-mediated crosstalk between DNA-damaged cells and their microenvironment.Frontiers in genetics · 2015Review
- Bystander communication and cell cycle decisions after DNA damage.Frontiers in genetics · 2015Article
- Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.Cancer letters · 2015Review
- Article
- Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.Cancer letters · 2014Article
- DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.PloS one · 2014Article
- The shape of the radiation dose response for DNA double-strand break induction and repair.Genome integrity · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Direct cellular DNA damage may lead to genome destabilization in unexposed, bystander, cells sharing the same milieu with directly damaged cells by means of the bystander effect. One proposed mechanism involves double strand break (DSB) formation in S phase cells at sites of single strand lesions in the DNA of replication complexes, which has a more open structure compared with neighboring DNA. The DNA in transcription complexes also has a more open structure, and hence may be susceptible to bystander DSB formation from single strand lesions. To examine whether transcription predisposes non-replicating cells to bystander effect-induced DNA DSBs, we examined two types of primary cells that exhibit high levels of transcription in the absence of replication, rat neurons and human lymphocytes. We found that non-replicating bystander cells with high transcription rates exhibited substantial levels of DNA DSBs, as monitored by γ-H2AX foci formation. Additionally, as reported in proliferating cells, TGF-β and NO were found to mimic bystander effects in cell populations lacking DNA synthesis. These results indicate that cell vulnerability to bystander DSB damage may result from transcription as well as replication. The findings offer insights into which tissues may be vulnerable to bystander genomic destabilization in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.