ReviewImmunologic research2013
Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire.
Review in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Distributed apoptotic checkpoints in B cell selection, tolerance, and autoimmunity.Frontiers in immunology · 2026Review
- Identification of immune cells in benign and malignant thymus tumors: a Mendelian randomization study.Annals of medicine and surgery (2012) · 2026Article
- Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome.Frontiers in immunology · 2025Article
- CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.ImmunoHorizons · 2023Article
- B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.Immunological reviews · 2022Review
- Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma.Frontiers in cell and developmental biology · 2022Article
- mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Cell circuits and niches controlling B cell development.Immunological reviews · 2019Review
- The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development.Frontiers in immunology · 2018Article
- Immunodeficiency in Bloom's Syndrome.Journal of clinical immunology · 2018Article
- Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo.PloS one · 2017Article
- γδ T Cells Shape Preimmune Peripheral B Cell Populations.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The ageing human B cell repertoire: a failure of selection?Clinical and experimental immunology · 2016Review
- New approaches for the immunotherapy of acute myeloid leukemia.Discovery medicine · 2015Review
- Human antibody production in transgenic animals.Archivum immunologiae et therapiae experimentalis · 2015Review
- Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Role of B lymphocytes in the pathogenesis of type 1 diabetes.Current diabetes reports · 2014Review
- Infection-induced changes in hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Immature B cells are generated daily in the bone marrow tissue. More than half of the newly generated immature B cells are autoreactive and bind a self-antigen, while the others are nonautoreactive. A selection process has evolved on the one hand to thwart development of autoreactive immature B cells and, on the other hand, to promote further differentiation of nonautoreactive immature B cells into transitional and mature B cells. These negative and positive selection events are carefully regulated by signals that emanate from the antigen receptor, whether antigen-mediated or tonic, and are influenced by signals that are generated by receptors that bind cytokines, chemokines, and other factors produced in the bone marrow tissue. These signals, therefore, are the predominant driving forces for the generation of a B cell population that is capable of protecting the body from infections while maintaining self-tolerance. Here, we review recent findings from our group and others that describe how tonic antigen receptor signaling and bone marrow cytokines regulate the selection of immature B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.