ArticlePediatric cardiology2013
Vitamin D deficiency is associated with increased left ventricular mass and diastolic dysfunction in children with chronic kidney disease.
Article in Pediatric cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Vitamin D Attenuates Left Atrial Volume Changes in African American Males with Obesity and Prediabetes.Echocardiography (Mount Kisco, N.Y.) · 2016Trial
- Vitamin D Deficiency and Clinical Outcomes in Critically Ill Pediatric Patients: A Systematic Review and Meta-Analysis.Journal of the Endocrine Society · 2025Review
- Article
- Cardiometabolic factors and vitamin D deficiency in pediatric patients with chronic kidney disease.Frontiers in nutrition · 2024Article
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- The Impact of Bone Mineral Biomarkers on Cardiac Dysfunction in Predialysis Chronic Kidney Disease Children.International journal of pediatrics · 2021Article
- Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study.BMC nephrology · 2020Observational
- Impact of parathyroidectomy on left ventricular function in end stage renal disease patients.BMC nephrology · 2020Article
- Vitamin D and Cardiovascular Risk: which Implications in Children?International journal of molecular sciences · 2020Review
- Vitamin D deficiency, cardiothoracic ratio, and long-term mortality in hemodialysis patients.Scientific reports · 2020Article
- Vitamin D and cardiovascular disease in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Cardiovascular risks in chronic kidney disease pediatric patients.Experimental and therapeutic medicine · 2017Article
- Oral paricalcitol: expanding therapeutic options for pediatric chronic kidney disease patients.Pediatric nephrology (Berlin, Germany) · 2017Article
- Fibroblast growth factor-23 and renin-angiotensin system levels in vitamin-D-dependent rickets type I.Pediatric nephrology (Berlin, Germany) · 2016Article
- The link between bone disease and cardiovascular complications in hemodialysis patients.Electronic physician · 2016Article
- Vitamin D nutritional status and the risk for cardiovascular disease.Experimental and therapeutic medicine · 2016Article
- Myocardial function in Saudi adolescents with vitamin D deficiency: Tissue Doppler imaging study.Journal of the Saudi Heart Association · 2016Article
- Vitamin D Level is Associated with Increased Left Ventricular Mass and Arterial Stiffness in Older Patients with Impaired Renal Function.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients.Anatolian journal of cardiology · 2015Observational
- Cardiorenal Syndrome and the Role of the Bone-Mineral Axis and Anemia.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease currently is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Abnormalities in arterial compliance, increased left ventricular mass, and diastolic dysfunction are some of the recognized cardiovascular complications observed in these patients. This study explored the relationship between various parameters of calcium-phosphorus metabolism including 25-hydroxy vitamin D and cardiovascular structure and function in pediatric patients with CKD. This cross-sectional study was conducted using a cohort of 34 children with CKD who had no history of underlying congenital or structural cardiac disease. Two-dimensional echocardiography was used to measure the left ventricular mass index (LVMI), E/A ratio, E', E/E' ratio, and myocardial performance index (MPI). The augmentation index (AI), derived via radial artery tonometry, was used as an indirect measure of central aortic stiffness. Serum biochemical markers of calcium-phosphorus metabolism were simultaneously measured. Univariate analysis showed that LVMI correlated with 25-hydroxy vitamin D (r = -0.54; p < 0.05), systolic blood pressure (SBP) (r = 0.36; p < 0.05), and AI (r = 0.26; p < 0.05). Serum-intact parathyroid hormone (PTH) levels correlated with the E/E' ratio (r = 0.63; p < 0.05) and E' (r = -0.61; p < 0.05). Multiple regression analysis showed that 25-hydroxy vitamin D and SBP were independent predictors of increased LVMI and that PTH was an independent predictor of diastolic dysfunction. This is the first study investigating pediatric patients with CKD that suggests an etiology of nutritional vitamin D deficiency associated with increased left ventricular mass and diastolic dysfunction. The cardiovascular changes observed are not easily reversible. Hence, early preventive therapy with vitamin D supplementation is advocated.
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