Evidence map›Paper›PMID 22941412›Full record

ReviewInternal and emergency medicine2012

Multiple systematic reviews: methods for assessing discordances of results.

Lorenzo Moja, M Pilar Fernandez del Rio, Rita Banzi, Cristina Cusi, Roberto D'Amico, Alessandro Liberati, Giovanni Lodi, Ersilia Lucenteforte, Silvia Minozzi, Valentina Pecoraro and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Internal and emergency medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. The effects of transcranial magnetic stimulation in motor symptoms of Parkinson's disease: an overview of systematic reviews with meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorenzo MojaDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy. lorenzo.moja@unimi.it
M Pilar Fernandez del Rio
Rita Banzi
Cristina Cusi
Roberto D'Amico
Alessandro Liberati
Giovanni Lodi
Ersilia Lucenteforte
Silvia Minozzi
Valentina Pecoraro
Gianni Virgili
Elena Parmelli

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe process of systematically reviewing research evidence is useful for collecting, assessing and summarizing results from multiple studies planned to answer the same clinical question. The term "systematic" implies that the process, besides being organized and complete, is transparent and fully reported to allow other independent researchers to replicate the results, and therefore come to the same conclusions. Hundreds of new systematic reviews are indexed every year. The growing number increases the likelihood of finding multiple and discordant results.

objectivesTo clarify the impact of multiple and discordant systematic reviews, we designed a program aimed at finding out: (a) how often different systematic reviews are done on the same subject; (b) how often different systematic reviews on the same topic give different results or conclusions; (c) which methods or interpretation characteristics can explain the differences in results or conclusions.

methodsThis paper outlines the method used to explore the frequency and the causes of discordance among multiple systematic reviews on the same topic. These methods were then applied to a few medical fields as case studies.

conclusionThis aim is particularly relevant for both clinicians and policy makers. Judgments about evidence and recommendation in health care are complex, and often rely on discordant results, especially when there are no empirical results to help serve as a guideline.

Indexed as

Reproducibility of ResultsResearch DesignReview Literature as TopicHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.