ArticleApplied and environmental microbiology2012
OmpA-mediated biofilm formation is essential for the commensal bacterium Sodalis glossinidius to colonize the tsetse fly gut.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- InferiorMicrobial genomics · 2024Pooled it
- PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies.PLoS pathogens · 2026Article
- Review
- Leveraging microbial ecology for mosquito-borne disease control.Trends in parasitology · 2025Review
- Virulence-linked adhesin drives mutualist colonization of the bee gut via biofilm formation.bioRxiv : the preprint server for biology · 2024Article
- Review
- Role of gut symbionts of insect pests: A novel target for insect-pest control.Frontiers in microbiology · 2023Review
- Interactions between Glossina pallidipes salivary gland hypertrophy virus and tsetse endosymbionts in wild tsetse populations.Parasites & vectors · 2022Article
- Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system.Microbiome · 2022Article
- Sodalis ligni Strain 159R Isolated from an Anaerobic Lignin-Degrading Consortium.Microbiology spectrum · 2022Article
- Molecular Insight into Gene Response of Diorcinol- and Rubrolide-Treated Biofilms of the Emerging Pathogen Stenotrophomonas maltophilia.Microbiology spectrum · 2022Article
- Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly's midgut environment.PLoS pathogens · 2021Article
- The genus Anaplasma: drawing back the curtain on tick-pathogen interactions.Pathogens and disease · 2021Review
- Genomes of Gut Bacteria frommSystems · 2021Article
- Roles of ompA of Citrobacter werkmanii in bacterial growth, biocide resistance, biofilm formation and swimming motility.Applied microbiology and biotechnology · 2021Article
- Molecular characterization and epitope-based vaccine predictions forIn silico pharmacology · 2021Article
- Growing Ungrowable Bacteria: Overview and Perspectives on Insect Symbiont Culturability.Microbiology and molecular biology reviews : MMBR · 2020Review
- Symbionts shape host innate immunity in honeybees.Proceedings. Biological sciences · 2020Article
- Resistance of Tick Gut Microbiome to Anti-Tick Vaccines, Pathogen Infection and Antimicrobial Peptides.Pathogens (Basel, Switzerland) · 2020Article
- Bacterial Symbionts of Tsetse Flies: Relationships and Functional Interactions Between Tsetse Flies and Their Symbionts.Results and problems in cell differentiation · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many bacteria successfully colonize animals by forming protective biofilms. Molecular processes that underlie the formation and function of biofilms in pathogenic bacteria are well characterized. In contrast, the relationship between biofilms and host colonization by symbiotic bacteria is less well understood. Tsetse flies (Glossina spp.) house 3 maternally transmitted symbionts, one of which is a commensal (Sodalis glossinidius) found in several host tissues, including the gut. We determined that Sodalis forms biofilms in the tsetse gut and that this process is influenced by the Sodalis outer membrane protein A (OmpA). Mutant Sodalis strains that do not produce OmpA (Sodalis ΔOmpA mutants) fail to form biofilms in vitro and are unable to colonize the tsetse gut unless endogenous symbiotic bacteria are present. Our data indicate that in the absence of biofilms, Sodalis ΔOmpA mutant cells are exposed to and eliminated by tsetse's innate immune system, suggesting that biofilms help Sodalis evade the host immune system. Tsetse is the sole vector of pathogenic African trypanosomes, which also reside in the fly gut. Acquiring a better understanding of the dynamics that promote Sodalis colonization of the tsetse gut may enhance the development of novel disease control strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.