ReviewPediatric nephrology (Berlin, Germany)2013
Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes.
Review in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pigeonetics takes flight: Evolution, development, and genetics of intraspecific variation.Developmental biology · 2017Review
- Growth and development. Bone dysplasia--a frequent cause of short stature in children.Nature reviews. Endocrinology · 2014Article
- Gene set analyses of genome-wide association studies on 49 quantitative traits measured in a single genetic epidemiology dataset.Genomics & informatics · 2013Article
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Abstract
Variation in adult height is not the most clinically relevant human quantitative trait, yet its study provides the foundation of many quantitative genetics theories and important statistical concepts (e.g. regression). Even today, the analysis of adult height by genome-wide association studies (GWAS) continues to significantly impact human genetics: these studies have led to the discovery of >200 loci associated with variation in adult height and have highlighted the very polygenic nature of human continuous traits. In this brief review, I discuss and provide examples on how such genetic associations, identified in individuals of normal height, could help understand the complex genetics behind such phenotypes as idiopathic short stature (ISS) or extreme/syndromic height phenotypes of unknown cause.
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