ReviewInternational urogynecology journal2013
Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse.
Review in International urogynecology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation.Journal of nanobiotechnology · 2024Article
- Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction.Bioengineering (Basel, Switzerland) · 2023Review
- Adipose-derived stromal cell in regenerative medicine: A review.World journal of stem cells · 2017Review
- Tissue-engineering with muscle fiber fragments improves the strength of a weak abdominal wall in rats.International urogynecology journal · 2017Article
- In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.International journal of molecular medicine · 2016Article
- In vivo effects of human adipose-derived stem cells reseeding on acellular bovine pericardium in nude mice.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Muscle fragments on a scaffold in rats: a potential regenerative strategy in urogynecology.International urogynecology journal · 2015Article
- Stem cell augmented mesh materials: an in vitro and in vivo study.International urogynecology journal · 2015Article
- hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold.Scientific reports · 2015Article
- To mesh or not to mesh: a review of pelvic organ reconstructive surgery.International journal of women's health · 2015Review
- Prevention and management of pelvic organ prolapse.F1000prime reports · 2014Review
- Evaluation of xenogenic extracellular matrices as adjuvant scaffolds for the treatment of stress urinary incontinence.International urogynecology journal · 2013Article
- Tissue engineering: creation of an autogenic collagenous neoligament for cure of urinary stress incontinence. Reply to Petros.International urogynecology journal · 2013Article
- Surgical treatment of pelvic organ prolapse: a historical review with emphasis on the anterior compartment.International urogynecology journal · 2013Review
- Tissue engineering: creation of an autogenic collagenous neoligament to cure urinary stress incontinence.International urogynecology journal · 2013Article
- Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse: comment on Boennelycke et al.International urogynecology journal · 2013Article
- Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse: reply to Osman et al.International urogynecology journal · 2013Article
- New strategies to improve results of mesh surgeries for vaginal prolapses repair--an update.International braz j urol : official journal of the Brazilian Society of UrologyReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisCell-based tissue engineering strategies could potentially provide attractive alternatives to surgical reconstruction of native tissue or the use of surgical implants in treating pelvic organ prolapse (POP).
methodsBased on a search in PubMed, this review focuses on candidate cell types, scaffolds, and trophic factors used in studies examining cell-based tissue engineering strategies to treat POP, stress urinary incontinence (SUI), and the closely related field of hernias.
resultsIn contrast to the field of SUI, the use of cell-based tissue engineering strategies to treat POP are very sparsely explored, and only preclinical studies exist.
conclusionThe available evidence suggests that the use of autologous muscle-derived cells, fibroblasts, or mesenchymal stem cells seeded on biocompatible, degradable, and potentially growth-promoting scaffolds could be an alternative to surgical reconstruction of native tissue or the use of conventional implants in treating POP. However, the vagina is a complex organ with great demands of functionality, and the perfect match of scaffold, cell, and trophic factor has yet to be found and tested in preclinical studies. Important issues such as safety and economy must also be addressed before this approach is ready for clinical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.