ReviewBiochemical pharmacology2013
Rhythm and blues: animal models of epilepsy and depression comorbidity.
Review in Biochemical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- The WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy: Sex Differences and Neurochemical Mechanisms.International journal of molecular sciences · 2026Article
- Bridging the Gap Between Depression and Epilepsy: A Call for Integrated Neuropsychiatric Care.Neuropsychiatric disease and treatment · 2026Article
- Strategic pathway analysis for dual management of epilepsy and comorbid depression: a systems biology perspective.In silico pharmacology · 2024Article
- Antidepressant Drugs for Seizures and Epilepsy: Where do we Stand?Current neuropharmacology · 2023Review
- Article
- Mechanisms of Psychiatric Comorbidities in Epilepsy.Current topics in behavioral neurosciences · 2022Article
- Inhibition of hyperactivity of the dorsal raphe 5-HTergic neurons ameliorates hippocampal seizure.CNS neuroscience & therapeutics · 2021Article
- Impact of Stress on Epilepsy: Focus on Neuroinflammation-A Mini Review.International journal of molecular sciences · 2021Review
- Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies.Frontiers in human neuroscience · 2021Article
- Depression and Anxiety in the Epilepsies: from Bench to Bedside.Current neurology and neuroscience reports · 2020Review
- Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model.Frontiers in molecular neuroscience · 2018Article
- Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice.Neurochemical research · 2016Article
- Single-Gene Determinants of Epilepsy Comorbidity.Cold Spring Harbor perspectives in medicine · 2015Review
- Article
- Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?Frontiers in pharmacology · 2015Review
- Animal models of epilepsy: use and limitations.Neuropsychiatric disease and treatment · 2014Review
- Serotonin and epilepsy: the story continues.Epilepsy currents · 2013Article
- Issues in Clinical Epileptology: A View from the Bench. A Festschrift in Honor of Philip A. Schwartzkroin, PhD.Epilepsy currents · 2013Article
- Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.Epilepsy & behavior : E&B · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Clinical evidence shows a strong, bidirectional comorbidity between depression and epilepsy that is associated with decreased quality of life and responsivity to pharmacotherapies. At present, the neurobiological underpinnings of this comorbidity remain hazy. To complicate matters, anticonvulsant drugs can cause mood disturbances, while antidepressant drugs can lower seizure threshold, making it difficult to treat patients suffering from both depression and epilepsy. Animal models have been created to untangle the mechanisms behind the relationship between these disorders and to serve as screening tools for new therapies targeted to treat both simultaneously. These animal models are based on chemical interventions (e.g. pentylenetetrazol, kainic acid, pilocarpine), electrical stimulations (e.g. kindling, electroshock), and genetic/selective breeding paradigms (e.g. genetically epilepsy-prone rats (GEPRs), genetic absence epilepsy rat from Strasbourg (GAERS), WAG/Rij rats, swim lo-active rats (SwLo)). Studies on these animal models point to some potential mechanisms that could explain epilepsy and depression comorbidity, such as various components of the dopaminergic, noradrenergic, serotonergic, and GABAergic systems, as well as key brain regions, like the amygdala and hippocampus. These models have also been used to screen possible therapies. The purpose of the present review is to highlight the importance of animal models in research on comorbid epilepsy and depression and to explore the contributions of these models to our understanding of the mechanisms and potential treatments for these disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.