ArticleCurrent biology : CB2012
Autonomous circuitry for substrate exploration in freely moving Drosophila larvae.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed.
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- Unsegmented marine annelids as biomechanical models for soft robotics.Scientific reports · 2026Article
- Finding a path: local search behavior of Drosophila larvae.The Journal of experimental biology · 2025Article
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- Triggering and modulation of a complex behavior by a single peptidergic command neuron inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae.Nature communications · 2025Article
- Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues.Nature communications · 2025Article
- Dual color optogenetic tool enables heart arrest, bradycardic, and tachycardic pacing in Drosophila melanogaster.Communications biology · 2024Article
- STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS.bioRxiv : the preprint server for biology · 2024Article
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- Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria.Nature communications · 2023Article
- Scanning behaviour in ants: an interplay between random-rate processes and oscillators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- High-resolution analysis of individualOpen biology · 2023Article
- Linking neural circuits to the mechanics of animal behavior inFrontiers in neural circuits · 2023Review
25 more citing papers are in PubMed but not listed here.
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Abstract
backgroundMany organisms, from bacteria to human hunter-gatherers, use specialized random walk strategies to explore their environment. Such behaviors are an efficient stratagem for sampling the environment and usually consist of an alternation between straight runs and turns that redirect these runs. Drosophila larvae execute an exploratory routine of this kind that consists of sequences of straight crawls, pauses, turns, and redirected crawls. Central pattern generating networks underlying rhythmic movements are distributed along the anteroposterior axis of the nervous system. The way in which the operation of these networks is incorporated into extended behavioral routines such as substrate exploration has not yet been explored. In particular, the part played by the brain in dictating the sequence of movements required is unknown.
resultsWe report the use of a genetic method to block synaptic activity acutely in the brain and subesophageal ganglia (SOG) of larvae during active exploratory behavior. We show that the brain and SOG are not required for the normal performance of an exploratory routine. Alternation between crawls and turns is an intrinsic property of the abdominal and/or thoracic networks. The brain modifies this autonomous routine during goal-directed movements such as those of chemotaxis. Nonetheless, light avoidance behavior can be mediated in the absence of brain activity solely by the sensorimotor system of the abdomen and thorax.
conclusionsThe sequence of movements for substrate exploration is an autonomous capacity of the thoracic and abdominal nervous system. The brain modulates this exploratory routine in response to environmental cues.
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