ArticleCurrent biology : CB2012
Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
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- An extra-clock ultradian brain oscillator sustains circadian timekeeping.Science advances · 2022Article
- Connectomic analysis of theeLife · 2022Article
- Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade.Current biology : CB · 2022Article
- A new player in circadian networks: Role of electrical synapses in regulating functions of the circadian clock.Frontiers in physiology · 2022Review
- Article
- Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics.Frontiers in molecular neuroscience · 2021Review
- Frontiers in Chronobiology: Endogenous Clocks at the Core of Signaling Pathways in Physiology.Frontiers in physiology · 2021Article
- Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.PLoS genetics · 2019Article
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- The circadian clock: A tale of genetic-electrical interplay and synaptic integration.Current opinion in physiology · 2018Article
- Calcium and cAMP directly modulate the speed of the Drosophila circadian clock.PLoS genetics · 2018Article
- Membrane Currents, Gene Expression, and Circadian Clocks.Cold Spring Harbor perspectives in biology · 2017Review
- Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundCircadian (∼24 hr) rhythms offer one of the best examples of how gene expression is tied to behavior. Circadian pacemaker neurons contain molecular clocks that control 24 hr rhythms in gene expression that in turn regulate electrical activity rhythms to control behavior.
resultsHere we demonstrate the inverse relationship: there are broad transcriptional changes in Drosophila clock neurons (LN(v)s) in response to altered electrical activity, including a large set of circadian genes. Hyperexciting LN(v)s creates a morning-like expression profile for many circadian genes while hyperpolarization leads to an evening-like transcriptional state. The electrical effects robustly persist in per(0) mutant LN(v)s but not in cyc(0) mutant LN(v)s, suggesting that neuronal activity interacts with the transcriptional activators of the core circadian clock. Bioinformatic and immunocytochemical analyses suggest that CREB family transcription factors link LN(v) electrical state to circadian gene expression.
conclusionsThe electrical state of a clock neuron can impose time of day to its transcriptional program. We propose that this acts as an internal zeitgeber to add robustness and precision to circadian behavioral rhythms.
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