Evidence map›Paper›PMID 22940462›Full record

Trial reportPain2012

Associations between daily chronic pain intensity, daily anger expression, and trait anger expressiveness: an ecological momentary assessment study.

Stephen Bruehl, Xiaoxia Liu, John W Burns, Melissa Chont, Robert N Jamison

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05025787 (EN20-01), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05025787 phase2completednot on this mapstarted 2021, after this paper: background citation

EN20-01: A 24 Week Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Moderate to Severe Knee Osteoarthritis Pain.

TypeinterventionalSponsorMaurizio Fava, MDRan2021 to 2024Enrolled55ConditionsKnee OsteoarthritisArmsCNTX-6970, Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  7. Effects of anger awareness and expression training versus relaxation training on headaches: a randomized trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2013
    Trial
  8. Article
  9. Review
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  17. Daily Links Between Sleep and Anger Among Spouses of Chronic Pain Patients.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen BruehlDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Behavioral Science, Rush University, Chicago, IL, USA.
Xiaoxia Liu
John W Burns
Melissa Chont
Robert N Jamison

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2KL2RR024977 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$3.0M
Predictors of Opioid Analgesic Responses and Common Endogenous Opioid MechanismsR01DA031726 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRUEHL, STEPHEN, BURNS, JOHN W. · 2011 to 2015
$2.7M
Anger Expression, Opioid Dysfunction, and Chronic PainR01NS050578 · NINDS · VANDERBILT UNIVERSITY · PI BRUEHL, STEPHEN · 2006 to 2009
$1.3M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) TL1TL1RR024978 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$1.3M
NCRR NIH HHS 1 UL1 RR024975NCRR NIH HHS KL2 RR024977NCRR NIH HHS TL1 RR024978NCRR NIH HHS UL1 RR024975NIDA NIH HHS R01 DA031726NIDA NIH HHS R01-DA031726NINDS NIH HHS R01 NS050578NINDS NIH HHS R01-NS050578
6 · The paper itself

Abstract

Links between elevated trait anger expressiveness (anger-out) and greater chronic pain intensity are well documented, but pain-related effects of expressive behaviors actually used to regulate anger when it is experienced have been little explored. This study used ecological momentary assessment methods to explore prospective associations between daily behavioral anger expression and daily chronic pain intensity. Forty-eight chronic low back pain (LBP) patients and 36 healthy controls completed electronic diary ratings of momentary pain and behavioral anger expression in response to random prompts 4 times daily for 7 days. Across groups, greater trait anger-out was associated with greater daily behavioral anger expression (P<0.001). LBP participants showed higher levels of daily anger expression than controls (P<0.001). Generalized estimating equation analyses in the LBP group revealed a lagged main effect of greater behavioral anger expression on increased chronic pain intensity in the subsequent assessment period (P<0.05). Examination of a trait×situation model for anger-out revealed prospective associations between elevated chronic pain intensity and later increases in behavioral anger expression that were restricted largely to individuals low in trait anger-out (P<0.001). Trait×situation interactions for trait anger suppression (anger-in) indicated similar influences of pain intensity on subsequent behavioral anger expression occurring among low anger-in persons (P<0.001). Overlap with trait and state negative affect did not account for study findings. This study for the first time documents lagged within-day influences of behavioral anger expression on subsequent chronic pain intensity. Trait anger regulation style may moderate associations between behavioral anger expression and chronic pain intensity.

Indexed as

AngerExpressed EmotionAdultCausalityChronic PainComorbidityFemaleHumansLow Back PainMalePain MeasurementPrevalenceRisk FactorsSeverity of Illness IndexTennesseeUnited States

Identifiers

PMID22940462
PMCPMC3586195

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.