ArticleJournal of controlled release : official journal of the Controlled Release Society2012
Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07615959 (Clinical Investigation to Evaluate the Safety, Tolerability and Performance of the Medicsen Smartpatch, a Non-Invasive Ultrasound-Based Drug Delivery Medical Device), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Investigation to Evaluate the Safety, Tolerability and Performance of the Medicsen Smartpatch, a Non-Invasive Ultrasound-Based Drug Delivery Medical Device (SOUNDD Study)
Who cites it
22 citing papers in PubMed.
- Battery-free and self-propelled bionic microneedle system for chemically controlled on-demand drug delivery.Microsystems & nanoengineering · 2025Article
- Harnessing Ultrasonic Technologies to TreatMolecules (Basel, Switzerland) · 2025Review
- Smart Ultrasound-responsive Polymers for Drug Delivery: An Overview on Advanced Stimuli-sensitive Materials and Techniques.Current drug delivery · 2025Review
- Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Advanced healthcare materials · 2024Review
- Sonosensitive Cavitation Nuclei-A Customisable Platform Technology for Enhanced Therapeutic Delivery.Molecules (Basel, Switzerland) · 2023Review
- Assessing the Dermal Penetration Efficacy of Chemical Compounds with the Ex-Vivo Porcine Ear Model.Pharmaceutics · 2022Article
- Low-Intensity Continuous Ultrasound Therapies—A Systematic Review of Current State-of-the-Art and Future Perspectives.Journal of clinical medicine · 2021Review
- Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies.Current drug delivery · 2019Review
- Electrically and Ultrasonically Enhanced Transdermal Delivery of Methotrexate.Pharmaceutics · 2018Article
- Recent advances in ultrasound-based transdermal drug delivery.International journal of nanomedicine · 2018Review
- Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment.Scientific reports · 2017Article
- A continuous glucose monitoring device by graphene modified electrochemical sensor in microfluidic system.Biomicrofluidics · 2016Article
- Treatment of chest wall tuberculosis with transdermal ultrasound-mediated drug delivery.Experimental and therapeutic medicine · 2015Article
- Applicability and safety of dual-frequency ultrasonic treatment for the transdermal delivery of drugs.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Relations between acoustic cavitation and skin resistance during intermediate- and high-frequency sonophoresis.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- Ultrasound-enhanced transdermal delivery: recent advances and future challenges.Therapeutic delivery · 2014Review
- A method for measuring the volume of transdermally extracted interstitial fluid by a three-electrode skin resistance sensor.Sensors (Basel, Switzerland) · 2014Article
- Skin permeabilization for transdermal drug delivery: recent advances and future prospects.Expert opinion on drug delivery · 2014Review
- Under the skin of intradermal vaccines.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Low-frequency ultrasound has been studied extensively due to its ability to enhance skin permeability. In spite of this effort, improvements in enhancing the efficacy of transdermal ultrasound treatments have been limited. Currently, when greater skin permeability is desired at a given frequency, one is limited to increasing the intensity or the duration of the ultrasound treatment, which carries the risk of thermal side effects. Therefore, the ability to increase skin permeability without increasing ultrasound intensity or treatment time would represent a significant and desirable outcome. Here, we hypothesize that the simultaneous application of two distinct ultrasound frequencies, in the range of 20 kHz to 3 MHz, can enhance the efficacy of ultrasound exposure. Aluminum foil pitting experiments showed a significant increase in cavitational activity when two frequencies were applied instead of just one low frequency. Additionally, in vitro tests with porcine skin indicated that the permeability and resulting formation of localized transport regions are greatly enhanced when two frequencies (low and high) are used simultaneously. These results were corroborated with glucose (180 Da) and inulin (5000 Da) transdermal flux experiments, which showed greater permeant delivery both into and through the dual-frequency pre-treated skin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.