ArticleNeuroImage2013
Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 230 citations in OpenAlex.
- Photobiomodulation on trigeminal neuralgia: systematic review.Lasers in medical science · 2021Pooled it
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- 3D-PAULM: Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy for Multiparametric Brain and Tumor Imaging.bioRxiv : the preprint server for biology · 2026Article
- Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Fast aberration correction in 3D transcranial photoacoustic computed tomography via a learning-based image reconstruction method.Photoacoustics · 2025Article
- Photoacoustic imaging of rat kidney tissue oxygenation using second near-infrared wavelengths.Journal of biomedical optics · 2025Article
- Noninvasive Intracranial Source Signal Localization and Decoding with High Spatiotemporal Resolution.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Tri-modalityPhotoacoustics · 2024Article
- Challenges and advances in two-dimensional photoacoustic computed tomography: a review.Journal of biomedical optics · 2024Review
- Article
- Label-free photoacoustic computed tomography of visually evoked responses in the primary visual cortex and four subcortical retinorecipient nuclei of anesthetized mice.Neurophotonics · 2024Article
- Oxygenation heterogeneity facilitates spatiotemporal flow pattern visualization inside human blood vessels using photoacoustic computed tomography.Biomedical optics express · 2024Article
- Longitudinal intravital imaging of mouse placenta.Science advances · 2024Article
- Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations.Epilepsia · 2024Review
- Light on Alzheimer's disease: from basic insights to preclinical studies.Frontiers in aging neuroscience · 2024Review
- Spiral laser scanning photoacoustic microscopy for functional brain imaging in rats.Neurophotonics · 2024Article
- Functional Photoacoustic Imaging for Placental Monitoring: A Mini Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Review
- FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.Nature communications · 2023Article
- Optoacoustic classification of diabetes mellitus with the synthetic impacts via optimized neural networks.Heliyon · 2023Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We have demonstrated the feasibility of imaging mouse brain metabolism using photoacoustic computed tomography (PACT), a fast, noninvasive and functional imaging modality with optical contrast and acoustic resolution. Brain responses to forepaw stimulations were imaged transdermally and transcranially. 2-NBDG, which diffuses well across the blood-brain-barrier, provided exogenous contrast for photoacoustic imaging of glucose response. Concurrently, hemoglobin provided endogenous contrast for photoacoustic imaging of hemodynamic response. Glucose and hemodynamic responses were quantitatively decoupled by using two-wavelength measurements. We found that glucose uptake and blood perfusion around the somatosensory region of the contralateral hemisphere were both increased by stimulations, indicating elevated neuron activity. While the glucose response area was more homogenous and confined within the somatosensory region, the hemodynamic response area had a clear vascular pattern and spread wider than the somatosensory region. Our results demonstrate that 2-NBDG-enhanced PACT is a promising tool for noninvasive studies of brain metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.