Trial reportBiological psychiatry2013
Acute nicotine differentially impacts anticipatory valence- and magnitude-related striatal activity.
Trial report in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A voxel-wise meta-analysis of task-based functional MRI studies on impaired gain and loss processing in adults with addiction.Journal of psychiatry & neuroscience : JPN · 2021Pooled it
- Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies.PloS one · 2021Pooled it
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Nicotine Increases Activation to Anticipatory Valence Cues in Anterior Insula and Striatum.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Trial
- Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers: A Randomized Trial.JAMA psychiatry · 2017Trial
- A Preliminary Examination of Reward Processing and Loneliness in Cigarette Smokers.Substance use & misuse · 2026Article
- Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.Frontiers in adolescent medicine · 2026Article
- Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Investigating the association between smoking, environmental tobacco smoke exposure and reward-related brain activity in adolescent experimental smokers.Addiction biology · 2022Article
- Anhedonia in Nicotine Dependence.Current topics in behavioral neurosciences · 2022Review
- Effects of environmental tobacco smoke exposure on brain functioning in never-smoking adolescents.Brain and behavior · 2020Article
- Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go-Nogo and Flanker tasks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder.Science advances · 2019Article
- The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study.Translational psychiatry · 2019Article
- Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review.Frontiers in psychiatry · 2019Review
- Functional Neurocircuits and Neuroimaging Biomarkers of Tobacco Use Disorder.Trends in molecular medicine · 2018Review
- Brain substrates of early (4h) cigarette abstinence: Identification of treatment targets.Drug and alcohol dependence · 2018Article
- Chronic Nicotine Alters Corticostriatal Plasticity in the Striatopallidal Pathway Mediated By NR2B-Containing Silent Synapses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDopaminergic activity plays a role in mediating the rewarding aspects of abused drugs, including nicotine. Nicotine modulates the reinforcing properties of other motivational stimuli, yet the mechanisms of this interaction are poorly understood. This study aimed to ascertain the impact of nicotine exposure on neuronal activity associated with reinforcing outcomes in dependent smokers.
methodsSmokers (n = 28) and control subjects (n = 28) underwent functional imaging during performance of a monetary incentive delay task. Using a randomized, counterbalanced design, smokers completed scanning after placement of a nicotine or placebo patch; nonsmokers were scanned twice without nicotine manipulation. In regions along dopaminergic pathway trajectories, we considered event-related activity for valence (reward/gain vs. punishment/loss), magnitude (small, medium, large), and outcome (successful vs. unsuccessful).
resultsBoth nicotine and placebo patch conditions were associated with reduced activity in regions supporting anticipatory valence, including ventral striatum. In contrast, relative to controls, acute nicotine increased activity in dorsal striatum for anticipated magnitude. Across conditions, anticipatory valence-related activity in the striatum was negatively associated with plasma nicotine concentration, whereas the number of cigarettes daily correlated negatively with loss anticipation activity in the medial prefrontal cortex only during abstinence.
conclusionsThese data suggest a partial dissociation in the state- and trait-specific effects of smoking and nicotine exposure on magnitude- and valence-dependent anticipatory activity within discrete reward processing brain regions. Such variability may help explain, in part, nicotine's impact on the reinforcing properties of nondrug stimuli and speak to the continued motivation to smoke and cessation difficulty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.