Evidence map›Paper›PMID 22939840›Full record

ReviewTrends in biochemical sciences2012

Selective translation during stress in Escherichia coli.

Isabella Moll, Hanna Engelberg-Kulka

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  10. Archives of molecular biology and genetics · 2022
    Article
  11. Review
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  13. Article
  14. Article
  15. The Dynamic SecYEG Translocon.Frontiers in molecular biosciences · 2021
    Review
  16. Article
  17. Bacterial stress defense: the crucial role of ribosome speed.Cellular and molecular life sciences : CMLS · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Isabella MollDepartment of Microbiology, Immunobiology and Genetics, Max F. Perutz Laboratories, University of Vienna, Dr. Bohrgasse 9, 1030 Vienna, Austria. Isabella.Moll@univie.ac.at
Hanna Engelberg-Kulka
Hebrew University of Jerusalem · ILMax Perutz Labs · AT

Funding

mazEF-mediated programmed cell death network in E. coliR01GM069509 · NIGMS · HEBREW UNIVERSITY OF JERUSALEM · PI ENGELBERG-KULKA, HANNA · 2007 to 2010
$616k
Austrian Science Fund FWF P 20112Austrian Science Fund FWF P 22249NIGMS NIH HHS GM069509NIGMS NIH HHS R01 GM069509
6 · The paper itself

Abstract

The bacterial stress response, a strategy to cope with environmental changes, is generally known to operate on the transcriptional level. Here, we discuss a novel paradigm for stress adaptation at the post-transcriptional level, based on the recent discovery of a stress-induced modified form of the translation machinery in Escherichia coli that is generated by MazF, the toxin component of the toxin-antitoxin (TA) module mazEF. Under stress, the induced endoribonuclease MazF removes the 3'-terminal 43 nucleotides of the 16S rRNA of ribosomes and, concomitantly, the 5'-untranslated regions (UTRs) of specific transcripts. This elegant mechanism enables selective translation due to the complementary effect of MazF on ribosomes and mRNAs, and also represents the first example of functional ribosome heterogeneity based on rRNA alteration.

Indexed as

Protein BiosynthesisStress, PhysiologicalEscherichia coliRibosomesRNA, BacterialRNA, MessengerRNA, BacterialRNA, Messenger

Identifiers

PMID22939840
PMCPMC4894542
OpenAlexW2048217869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.