ArticleCell2012
Holding on through DNA replication: histone modification or modifier?
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Histone Deacetylase Inhibitor, Trichostatin A, Synergistically Enhances Paclitaxel-Induced Cytotoxicity in Urothelial Carcinoma Cells by Suppressing the ERK Pathway.International journal of molecular sciences · 2019Article
- Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.Cell cycle (Georgetown, Tex.) · 2017Article
- Forks on the Run: Can the Stalling of DNA Replication Promote Epigenetic Changes?Frontiers in genetics · 2017Review
- ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.Cell reports · 2015Article
- Epigenetic mechanisms in diabetic complications and metabolic memory.Diabetologia · 2015Review
- Association of ORCA/LRWD1 with repressive histone methyl transferases mediates heterochromatin organization.Nucleus (Austin, Tex.) · 2015Article
- Epigenetics: Beyond Chromatin Modifications and Complex Genetic Regulation.Plant physiology · 2014Review
- Epigenetic modifications in the pathogenesis of diabetic nephropathy.Seminars in nephrology · 2013Review
- Transcription and replication result in distinct epigenetic marks following repression of early gene expression.Frontiers in genetics · 2013Article
- An emerging paradigm in epigenetic marking: coordination of transcription and replication.TranscriptionReview
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.
Identifiers
22939615What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.