ArticleJournal of cardiac failure2012
Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.
Article in Journal of cardiac failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045043 (Genetic Risk Assessment of Defibrillator Events), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Risk Assessment of Defibrillator Events: A Prospective Multicenter Observational Study
Who cites it
19 citing papers in PubMed.
- Genetic and Molecular Mechanisms of Non-Ischemic Heart Failure with Preserved Ejection Fraction: Pathway Crosstalk, Translational Implications, and Regional Genetic Context.International journal of molecular sciences · 2026Review
- The Heart's Small Molecules: The Importance of MicroRNAs in Cardiovascular Health.Journal of clinical medicine · 2025Review
- From Natriuretic Peptides to microRNAs: Multi-Analyte Liquid Biopsy Horizons in Heart Failure.Biomolecules · 2025Review
- Non-coding RNA and arrhythmias: expression, function, and molecular mechanism.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Review
- Allele С (rs5186) of at1r is associated with the severity of COVID-19 in the Ukrainian population.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022Observational
- Schisandrin A protects against isoproterenol‑induced chronic heart failure via miR‑155.Molecular medicine reports · 2022Article
- ETS2 and microRNA-155 regulate the pathogenesis of heart failure through targeting and regulating GPR18 expression.Experimental and therapeutic medicine · 2020Article
- Combined detection of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 for screening of early heart failure diseases.Bioscience reports · 2020Article
- Tai Chi Ameliorates Coronary Heart Disease by Affecting Serum Levels of miR-24 and miR-155.Frontiers in physiology · 2019Article
- The Relationship between Angiotensin-II Type 1 Receptor Gene Polymorphism and Repolarization Parameters after a First Anterior Acute Myocardial Infarction.Korean circulation journal · 2016Article
- Genetic variations involved in sudden cardiac death and their associations and interactions.Heart failure reviews · 2016Review
- KCNN2 polymorphisms and cardiac tachyarrhythmias.Medicine · 2016Article
- Diagnostic, Prognostic, and Therapeutic Value of Circulating miRNAs in Heart Failure Patients Associated with Oxidative Stress.Oxidative medicine and cellular longevity · 2016Review
- Preparation and Biological Activity of the Monoclonal Antibody against the Second Extracellular Loop of the Angiotensin II Type 1 Receptor.Journal of immunology research · 2016Article
- Race, common genetic variation, and therapeutic response disparities in heart failure.JACC. Heart failure · 2014Review
- Stratification of the risk of sudden death in nonischemic heart failure.Arquivos brasileiros de cardiologia · 2014Review
- Genetics and epigenetics of arrhythmia and heart failure.Frontiers in genetics · 2013Review
- Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).PloS one · 2013Article
- Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fibrotic response in diabetic hearts.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundSudden cardiac death (SCD) from ventricular tachyarrhythmias accounts for approximately 450,000 annual deaths in the United States; many of these cases involve patients with chronic heart failure (HF). Prediction of which HF patients are most susceptible to SCD is difficult, and it is uncertain whether gene polymorphisms associated with HF outcomes are also linked to arrhythmic risk.
methodsWe evaluated 485 patients with chronic HF to see whether the angiotensin receptor type 1 (AT1R) 1166A/C or angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms were associated with a higher rate of ventricular arrhythmias requiring implantable cardioverter defibrillator (ICD) therapies over a 5-year period. We assessed the correlation between polymorphisms and antitachycardia pacing (ATP) and/or ICD shocks.
resultsPatients with AT1R-1166CC genotype had an increased rate of all events: ATP plus ICD shocks (P = .02). There was no association between ACE I/D genotype and ICD therapies. Furthermore, circulating levels of microRNA-155 (miR-155), a microRNA known to posttranscriptionally regulate AT1R expression, were significantly decreased in the CC compared with the AC and AA genotypes and were associated with ICD events.
conclusionOur study suggests that the AT1R-1166CC genotype is associated with increased ICD therapies in patients with chronic HF, and the level of circulating miR-155 may be a potential marker for arrhythmic risk. Although these findings are novel, they will need replication and validation in larger cohorts of chronic HF patients.
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