ArticleJournal of cardiac failure2012
Fatigue, inflammation, and projected mortality in heart failure.
Article in Journal of cardiac failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Fatigue in Persons With Heart Failure: A Systematic Literature Review and Meta-Synthesis Using the Biopsychosocial Model of Health.Journal of cardiac failure · 2022Pooled it
- A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness.Biological research for nursing · 2018Pooled it
- Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Trial
- Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension.Annals of the American Thoracic Society · 2015Trial
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise.Journal of dietary supplements · 2013Trial
- Factors Associated With Fatigue in Persons With Atrial Fibrillation in the Atherosclerosis Risk in Communities (ARIC) Study.Biological research for nursing · 2024Article
- Exercises in activating lymphatic system on fluid overload symptoms, abnormal weight gains, and physical functions among patients with heart failure: A randomized controlled trial.Frontiers in cardiovascular medicine · 2023Article
- Sleep Deficiency: A Symptoms Perspective: Exemplars from Chronic Heart Failure, Inflammatory Bowel Disease, and Breast Cancer.Clinics in chest medicine · 2022Review
- Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure.Journal of clinical medicine · 2021Article
- Factors related to perceived control and health-related quality of life of patients after acute coronary syndrome during admission and after discharge.Japan journal of nursing science : JJNS · 2021Article
- Fatigue Is Common in Immunoglobulin G Subclass Deficiency and Correlates With Inflammatory Response and Need for Immunoglobulin Replacement Therapy.Frontiers in immunology · 2021Article
- The relevance of serum albumin among elderly patients with acute decompensated heart failure.Journal of geriatric cardiology : JGC · 2019Article
- Increased Incidence of Fatigue in Patients with Primary Immunodeficiency Disorders: Prevalence and Associations Within the US Immunodeficiency Network Registry.Journal of clinical immunology · 2017Article
- Differing Effects of Fatigue and Depression on Hospitalizations in Men and Women With Heart Failure.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2016Article
- Depressive symptoms and the relationship of inflammation to physical signs and symptoms in heart failure patients.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2014Observational
- Promoting self-management through adherence among heart failure patients discharged from rural hospitals: a study protocol.F1000Research · 2014Article
- Inflammation markers associated with symptoms and neighborhood deprivation in black adults with heart failure.Heart & lung : the journal of critical careArticle
- Article
- The Associations of Diagnoses of Fatigue and Depression With Use of Medical Services in Patients With Heart Failure.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFatigue is a prominent and poorly understood symptom of heart failure with reduced ejection fraction (HFrEF). The purpose of this study was to determine whether fatigue correlated with immune biomarkers and prognosis. METHODS/
resultsIn patients with HFrEF (N = 59) and healthy controls (N = 25), we prospectively measured fatigue (Profile of Mood States), depressive symptoms (Patient Health Questionnaire-8), sleep quality (Pittsburgh Sleep Quality Index), and immune biomarkers (plasma C-reactive protein [CRP], tumor necrosis factor-α [TNFα], and interleukins [IL-6 and IL-10]). Seattle Heart Failure Model (SHFM) mortality risk scores were determined. Patients with HFrEF had significantly greater fatigue and depressive symptoms and poorer sleep quality compared to control subjects. When controlling for depressive symptoms, however, fatigue did not differ significantly between patients with HFrEF and controls. Patients with HFrEF had significantly lower levels of IL-10 compared to controls. Cytokines did not correlate significantly with fatigue, but fatigue was significantly associated with higher SHFM scores.
conclusionsDepressive symptoms were an important covariate of fatigue in patients with HFrEF. Our study findings were the first to show a positive association between fatigue and the SHFM score, indicating that fatigue was associated with poorer prognosis.
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Registered trials
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