ArticleSurgery2012
The effect of depression on stage at diagnosis, treatment, and survival in pancreatic adenocarcinoma.
Article in Surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Depression on Mortality in Patients with Pancreatic Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Trajectories of quality of life in pancreatic cancer survivors during the first year after surgery: a longitudinal study.Scientific reports · 2026Article
- Effect of postoperative esketamine on depression after pancreatoduodenectomy: a randomized controlled trial.Perioperative medicine (London, England) · 2026Article
- Inflammation-associated depression in cholangiocarcinoma: impacts of surgical resection and radiotherapy.BioPsychoSocial medicine · 2026Article
- Association of peripheral inflammatory cell counts with depression among cancer survivors: a cross-sectional study based on the NHANES dataset.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Machine Learning-Based Classification of Depression Using Inflammatory Biomarkers in Pancreatic Cancer Patients.The Kaohsiung journal of medical sciences · 2026Article
- The impact of anxiety and affective disorders on breast cancer screening in women in Puerto Rico.PloS one · 2026Article
- Review
- Cancer stage at diagnosis by duration of pre-existing chronic analgesic use and anxiety or depression.Nature communications · 2025Article
- The Presence or Absence of Household Members Is a Factor That Influences Treatment Decisions in Patients with Pancreatic Cancer.Internal medicine (Tokyo, Japan) · 2025Article
- Lifetime stressor exposure and depression among patients with pancreatic cancer: insights from the Florida Pancreas Collaborative.BMC cancer · 2025Article
- Unusual Manifestations of Primary Pancreatic Neoplasia.Cancers · 2025Review
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Predictors of Psychiatric Complications in Patients with Pancreatic Cancer: A Retrospective Cohort Study.Actas espanolas de psiquiatria · 2024Article
- Cancer diagnosis after emergency presentations in people with mental health and substance use conditions: a national cohort study.BMC cancer · 2024Article
- Overall and Cervical Cancer Survival in Patients With and Without Mental Disorders.JAMA network open · 2023Article
- Article
- Pancreatic cancer and depression.World journal of clinical cases · 2023Review
- Pancreatic cancer progression and mortality predicted by depression and anxiety: a systematic review and meta-analysis protocol.Frontiers in psychiatry · 2023Article
- Mental health disorders among ovarian cancer survivors in a population-based cohort.Cancer medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDepression has been associated with delayed presentation, inadequate treatment, and poor survival in patients with cancer.
methodsUsing Surveillance, Epidemiology and End Results and Medicare linked data (1992-2005), we identified patients with pancreatic adenocarcinoma (N = 23,745). International classification of diseases, 9th edition, clinical modification codes were used to evaluate depression during the 3 to 27 months before the diagnosis of cancer. The effect of depression on receipt of therapy and survival was evaluated in univariate and multivariate models.
resultsOf patients with pancreatic cancer in our study, 7.9% had a diagnosis of depression (N = 1,868). Depression was associated with increased age, female sex, white race, single or widowed status, and advanced stage disease (P < .0001). In an adjusted model, patients with locoregional disease and depression had 37% lower odds of undergoing surgical resection (odds ratio, 0.63; 95% confidence interval, 0.52-0.76). In patients with locoregional disease, depression was associated with lower 2-year survival (hazard ratio, 1.20; 95% confidence interval, 1.09-1.32). After adjusting for surgical resection, this association was attenuated (hazard ratio, 1.14; 95% confidence interval, 1.04-1.26). In patients who underwent surgical resection, depression was a significant predictor of survival (hazard ratio, 1.34; 95% confidence interval, 1.04-1.73). Patients with distant disease and depression had 21% lower odds of receiving chemotherapy (odds ratio, 0.79; 95% confidence interval, 0.70-0.90). After adjusting for chemotherapy for distant disease, depression was no longer a significant predictor of survival (hazard ratio, 1.03; 95% confidence interval, 0.97-1.09).
conclusionThe decreased survival associated with depression appears to be mediated by a lower likelihood of appropriate treatment in depressed patients. Accurate recognition and treatment of pancreatic cancer patients with depression may improve treatment rates and survival.
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