ArticleBosnian journal of basic medical sciences2012
Mitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age.
Article in Bosnian journal of basic medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- The nuclear and mitochondrial genomes need to tango. How is their dance synchronized during development?NAR molecular medicine · 2026Article
- Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats.Biogerontology · 2024Article
- The role of mtDNA in oocyte quality and embryo development.Molecular reproduction and development · 2023Review
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- Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis.Redox biology · 2020Review
- Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence.Frontiers in endocrinology · 2019Review
- Review
- Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke.PloS one · 2018Article
- Mitochondrial injury and cognitive function in HIV infection and methamphetamine use.AIDS (London, England) · 2016Article
- Differential mtDNA damage patterns in a transgenic mouse model of Machado-Joseph disease (MJD/SCA3).Journal of molecular neuroscience : MN · 2015Article
- Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice.Aging and disease · 2013Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial DNA (mtDNA) is believed to be particularly susceptible to oxidative damage during aging, resulting in mtDNA point mutations, duplications, and deletions. Although mtDNA deletions have been reported in various human tissues, e.g., the brain, heart, and skeletal muscle, little is known about the occurrence in hair. Therefore, we screened for the presence of mtDNA 13162 bp, 10422 bp, 7663 bp, 7436 bp, 4989 bp, and 4977 bp deletions in 90 hair samples from subjects aged 5 days to 91 years by using polymerase chain reaction (PCR) and investigated the deletion load by TaqMan probe-based real-time PCR. We detected the mtDNA 4977 bp deletion in hair samples, but none of the other deletions that were screened for. The proportion of mtDNA 4977 deletion carriers was 98.3% (89/90) and the deletion loads increased from 0 to 1.436 ± 0.2086% of the total mtDNA with an exponential increase with age (r = 0.677, p < 0.05). These results suggest that mtDNA 4977 bp deletion is a common phenomenon in hair and increases with age. These findings expand our understanding of the tissue-specific distribution of mtDNA deletions.
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