ArticleBipolar disorders2012
Mental disorders in offspring of parents with bipolar and major depressive disorders.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Risk of Disruptive Behavioral Disorders in the Offspring of Parents with Severe Psychiatric Disorders.Child psychiatry and human development · 2021Pooled it
- Prevalence of psychopathology in bipolar high-risk offspring and siblings: a meta-analysis.European child & adolescent psychiatry · 2018Pooled it
- Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies.Schizophrenia bulletin · 2014Pooled it
- Childhood Maltreatment in the Context of Familial Bipolar I Disorder Risk Predicts Major Depressive Disorder in Adolescents.JAACAP open · 2026Article
- Familial Transmission of Major Depression and Bipolar Disorder to Alcohol and Other Drug Use Disorders in a Swedish National Sample: Strongest Effects From Mothers to Daughters.Journal of studies on alcohol and drugs · 2026Article
- Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety.Nature communications · 2026Article
- Ripples across generations: offspring outcomes after parental infant institutionalisation-study protocol of the LifeStories Offspring Project.Frontiers in psychology · 2026Article
- Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression.BMJ mental health · 2025Article
- Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study.European child & adolescent psychiatry · 2025Article
- Barriers to participating in an online family- and group-based prevention programme for parents with depression: an online survey.BMC psychology · 2025Article
- Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.Bipolar disorders · 2025Article
- Article
- Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder: a high-risk study in the Chinese population.General psychiatry · 2024Article
- Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders.JAMA network open · 2023Article
- The temporal dependencies between social, emotional and physical health factors in young people receiving mental healthcare: a dynamic Bayesian network analysis.Epidemiology and psychiatric sciences · 2023Article
- Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder.European child & adolescent psychiatry · 2023Article
- The impact of early life stress and schizophrenia on motor and cognitive functioning: an experimental study.Frontiers in integrative neuroscience · 2023Article
- Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.International journal of bipolar disorders · 2022Article
- Families With Violence Exposure and the Intergenerational Transmission of Somatization.Frontiers in psychiatry · 2022Article
- Associations Between Maternal Post-traumatic Stress Disorder and Traumatic Events With Child Psychopathology: Results From a Prospective Longitudinal Study.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesThere is limited information on the specificity of associations between parental bipolar disorder (BPD) and major depressive disorder (MDD) and the risk of psychopathology in offspring. The chief aim of the present study was to investigate the association between mood disorder subtypes in the two parents and mental disorders in the offspring.
methodsA total of 376 offspring (aged 6.0-17.9 years; mean=11.5years) of 72 patients with BPD (139 offspring), 56 patients with MDD (110 offspring), and 66 controls (127 offspring) participated in a family study conducted in two university hospital centers in Switzerland. Probands, offspring, and biological co-parents were interviewed by psychologists blind to proband diagnoses, using a semi-structured diagnostic interview.
resultsRates of mood and anxiety disorders were elevated among offspring of BPD probands (34.5% any mood; 42.5% any anxiety) and MDD probands (25.5% any mood; 44.6% any anxiety) as compared to those of controls (12.6% any mood; 22.8% any anxiety). Moreover, recurrent MDD was more frequent among offspring of BPD probands (7.9%) than those of controls (1.6%). Parental concordance for bipolar spectrum disorders was associated with a further elevation in the rates of mood disorders in offspring (64.3% both parents versus 27.2% one parent).
conclusionsThese findings provide unique information on the broad manifestations of parental mood disorders in their offspring. The earlier onset and increased risk of recurrent MDD in the offspring of parents with BPD compared to those of controls suggests that the episodicity characterizing BPD may emerge in childhood and adolescence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.