ArticleBipolar disorders2012
Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data.Neuroscience and biobehavioral reviews · 2018Pooled it
- Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls.Schizophrenia bulletin · 2015Pooled it
- Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents.European child & adolescent psychiatry · 2014Pooled it
- Brain, behavioral, affective, and sex correlates of recovery from alcohol use disorders.Alcoholism, clinical and experimental research · 2021Article
- The error-related negativity (ERN) is an electrophysiological marker of motor impulsiveness on the Barratt Impulsiveness Scale (BIS-11) during adolescence.Developmental cognitive neuroscience · 2018Article
- Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Effects of ANK3 variation on gray and white matter in bipolar disorder.Molecular psychiatry · 2017Article
- Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females.Brain structure & function · 2016Article
- Anterior Cortical Development During Adolescence in Bipolar Disorder.Biological psychiatry · 2016Article
- Can Emotional and Behavioral Dysregulation in Youth Be Decoded from Functional Neuroimaging?PloS one · 2016Article
- Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder: a voxel-based morphometry study.Neuroscience bulletin · 2015Article
- White matter abnormalities: Insights into the pathophysiology of major affective disorders.World journal of radiology · 2014Article
- White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms.Molecular psychiatry · 2014Article
- The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Reduced serum levels of neuron specific enolase (NSE) in drug-naïve subjects with major depression and bipolar disorder.Neurochemical research · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesA range of prefrontal and subcortical volumetric abnormalities have been found in adults and adolescents with bipolar disorder. It is unclear, however, if these deficits are present early in the onset of mania or are a consequence of multiple mood episodes or prolonged exposure to medication. The goal of this study was to examine whether youth with bipolar I disorder who recently experienced their first episode of mania are characterized by brain volumetric abnormalities.
methodsAnatomical images from magnetic resonance imaging of 26 13- to 18-year-old adolescents with bipolar I disorder and 24 age-comparable healthy controls with no personal or family history of psychopathology were analyzed using whole-brain voxel-based morphometry (VBM).
resultsCompared with healthy controls, adolescents with bipolar I disorder had significantly less gray matter volume in the left subgenual cingulate cortex [p<0.05, family-wise error (FWE)-corrected].
conclusionsAdolescents with a recent single episode of mania have smaller subgenual cingulate cortex volume than do their healthy counterparts, suggesting that this anomaly occurs early in the onset of, or may predate the disorder. Longitudinal studies are needed to examine the impact of this volumetric reduction on the course and outcome of this disorder.
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