ArticleJournal of anatomy2012
Anatomical, architectural, and biochemical diversity of the murine forelimb muscles.
Article in Journal of anatomy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 69 citations in OpenAlex.
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- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat.The Journal of physiology · 2025Article
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- ROLE OF FORELIMB MORPHOLOGY IN MUSCLE SENSORIMOTOR FUNCTIONS DURING LOCOMOTION IN THE CAT.bioRxiv : the preprint server for biology · 2024Article
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- Myomatrix arrays for high-definition muscle recording.bioRxiv : the preprint server for biology · 2023Article
- Three-dimensional mapping reveals heterochronic development of the neuromuscular system in postnatal mouse skeletal muscles.Communications biology · 2022Article
- Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling.Nature communications · 2022Article
- From fibre to function: are we accurately representing muscle architecture and performance?Biological reviews of the Cambridge Philosophical Society · 2022Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
We characterized the architecture, fiber type, titin isoform distribution, and collagen content of 27 portions of 22 muscles in the murine forelimb. The mouse forelimb was different from the human arm in that it had the extensor digitorum lateralis muscle and no brachioradialis muscle. Architecturally, the mouse forelimb differed from humans with regard to load bearing, having a much larger contribution from extensors than flexors. In mice, the extensor : flexor PCSA ratio is 2.7, whereas in humans it is only 1.4. When the architectural difference index was calculated, similarities became especially apparent between flexors and extensors of the distal forelimb, as well as pronators. Discriminant analysis revealed that biochemical measures of collagen, titin, and myosin heavy chain were all strong between-species discriminators. In terms of composition, when compared with similar muscles in humans, mice had, on average, faster muscles with higher collagen content and larger titin isoforms. This report establishes the anatomical and biochemical properties of mouse forelimb muscles. Given the prevalence of this species in biological studies, these data will be invaluable for studying the biological basis of mouse muscle structure and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.