ArticleThe Analyst2012
Electrokinetic focusing and separation of mammalian cells in conductive biological fluids.
Article in The Analyst, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- A Bionic Sensing Platform for Cell Separation: Simulation of a Dielectrophoretic Microfluidic Device That Leverages Dielectric Fingerprints.Biomimetics (Basel, Switzerland) · 2025Article
- Enhancing cell characterization with microfluidics and AI: a comprehensive review of mechanical, electrical, and hybrid techniques.Biotechnology reports (Amsterdam, Netherlands) · 2025Review
- Microfluidic Technologies in Advancing Cancer Research.Micromachines · 2024Review
- Pneumatically Driven Microfluidic Platform and Fully Automated Particle Concentration System for the Capture and Enrichment of Pathogens.ACS omega · 2023Article
- A dielectrophoresis-based microfluidic system having double-sided optimized 3D electrodes for label-free cancer cell separation with preserving cell viability.Scientific reports · 2022Article
- Article
- Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution.Pharmaceutics · 2020Article
- Microfluidic Single-Cell Manipulation and Analysis: Methods and Applications.Micromachines · 2019Review
- Nanoscale tweezers for single-cell biopsies.Nature nanotechnology · 2019Article
- Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling.Biophysical journal · 2016Review
- Long-range electrothermal fluid motion in microfluidic systems.International journal of heat and mass transfer · 2016Article
- AC Electrokinetics of Physiological Fluids for Biomedical Applications.Journal of laboratory automation · 2015Review
- Hydrodynamic self-focusing in a parallel microfluidic device through cross-filtration.Biomicrofluidics · 2015Article
- Combining electrochemical sensors with miniaturized sample preparation for rapid detection in clinical samples.Sensors (Basel, Switzerland) · 2014Review
- Microfluidic blood cell sorting: now and beyond.Small (Weinheim an der Bergstrasse, Germany) · 2014Review
- Advances and challenges in biosensor-based diagnosis of infectious diseases.Expert review of molecular diagnostics · 2014Review
- Rapid and label-free separation of Burkitt's lymphoma cells from red blood cells by optically-induced electrokinetics.PloS one · 2014Article
- A Universal Electrode Approach for Automated Electrochemical Molecular Analyses.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2013Article
- Recent advances in microfluidic cell separations.The Analyst · 2013Review
- An AC electrokinetics facilitated biosensor cassette for rapid pathogen identification.The Analyst · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Active manipulation of cells, such as trapping, focusing, and isolation, is essential for various bioanalytical applications. Herein, we report a hybrid electrokinetic technique for manipulating mammalian cells in physiological fluids. This technique applies a combination of negative dielectrophoretic force and hydrodynamic drag force induced by electrohydrodynamics, which is effective in conductive biological fluids. With a three-electrode configuration, the stable equilibrium positions of cells can be adjusted for separation and focusing applications. Cancer cells and white blood cells can be positioned and isolated into specific locations in the microchannel under both static and dynamic flow conditions. To investigate the sensitivity of the hybrid electrokinetic process, AC voltage, frequency, and bias dependences of the cell velocity were studied systematically. The applicability of the hybrid electrokinetic technique for manipulating cells in physiological samples is demonstrated by continuous focusing of human breast adenocarcinoma spiked in urine, buffy coats, and processed blood samples with 98% capture efficiency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.