ArticleTranslational oncology2012
An integrated method for reproducible and accurate image-guided stereotactic cranial irradiation of brain tumors using the small animal radiation research platform.
Article in Translational oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research.International journal of radiation oncology, biology, physics · 2021Article
- Establishment and Validation of CyberKnife Irradiation in a Syngeneic Glioblastoma Mouse Model.Cancers · 2021Article
- Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain.International journal of molecular sciences · 2020Article
- Article
- Contrast-enhanced, conebeam CT-based, fractionated radiotherapy and follow-up monitoring of orthotopic mouse glioblastoma: a proof-of-concept study.Radiation oncology (London, England) · 2020Article
- Preclinical dosimetry: exploring the use of small animal phantoms.Radiation oncology (London, England) · 2019Review
- Magnetic resonance imaging-guided radiation therapy using animal models of glioblastoma.The British journal of radiology · 2019Review
- The Path Toward PET-Guided Radiation Therapy for Glioblastoma in Laboratory Animals: A Mini Review.Frontiers in medicine · 2019Review
- Assessing the Validity of Clinician Advice That Patients Avoid Use of Topical Agents Before Daily Radiotherapy Treatments.JAMA oncology · 2018Article
- Development of whole brain versus targeted dentate gyrus irradiation model to explain low to moderate doses of exposure effects in mice.Scientific reports · 2018Article
- Velocity-based Adaptive Registration and Fusion for Fractionated Stereotactic Radiosurgery Using the Small Animal Radiation Research Platform.International journal of radiation oncology, biology, physics · 2018Article
- PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator.Journal of visualized experiments : JoVE · 2017Article
- Multi-institutional MicroCT image comparison of image-guided small animal irradiators.Physics in medicine and biology · 2017Article
- Development and Validation of a Small Animal Immobilizer and Positioning System for the Study of Delivery of Intracranial and Extracranial Radiotherapy Using the Gamma Knife System.Technology in cancer research & treatment · 2017Article
- An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.PloS one · 2017Article
- Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance.Radiation research · 2016Article
- Systematic study of target localization for bioluminescence tomography guided radiation therapy.Medical physics · 2016Article
- Bioluminescence Tomography-Guided Radiation Therapy for Preclinical Research.International journal of radiation oncology, biology, physics · 2016Article
- Theranostic Application of Mixed Gold and Superparamagnetic Iron Oxide Nanoparticle Micelles in Glioblastoma Multiforme.Journal of biomedical nanotechnology · 2016Article
- A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Preclinical studies of cranial radiation therapy (RT) using animal brain tumor models have been hampered by technical limitations in the delivery of clinically relevant RT. We established a bioimageable mouse model of glioblastoma multiforme (GBM) and an image-guided radiation delivery system that facilitated precise tumor localization and treatment and which closely resembled clinical RT. Our novel radiation system makes use of magnetic resonance imaging (MRI) and bioluminescent imaging (BLI) to define tumor volumes, computed tomographic (CT) imaging for accurate treatment planning, a novel mouse immobilization system, and precise treatments delivered with the Small Animal Radiation Research Platform. We demonstrated that, in vivo, BLI correlated well with MRI for defining tumor volumes. Our novel restraint system enhanced setup reproducibility and precision, was atraumatic, and minimized artifacts on CT imaging used for treatment planning. We confirmed precise radiation delivery through immunofluorescent analysis of the phosphorylation of histone H2AX in irradiated brains and brain tumors. Assays with an intravenous near-infrared fluorescent probe confirmed that radiation of orthografts increased disruption of the tumor blood-brain barrier (BBB). This integrated model system, which facilitated delivery of precise, reproducible, stereotactic cranial RT in mice and confirmed RT's resultant histologic and BBB changes, may aid future brain tumor research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.